Full metadata record
DC FieldValueLanguage
dc.creatorBarea, C. (Carlos)-
dc.creatorPabon, A. (Adriana)-
dc.creatorCastillo, D. (Denis)-
dc.creatorZimic, M. (Mirko)-
dc.creatorGaliano, S. (Silvia)-
dc.creatorPérez-Silanes, S. (Silvia)-
dc.creatorMonge, A. (Antonio)-
dc.creatorDeharo, E. (Eric)-
dc.creatorAldana, I. (Ignacio)-
dc.date.accessioned2021-07-23T11:45:11Z-
dc.date.available2021-07-23T11:45:11Z-
dc.date.issued2011-
dc.identifier.citationBioorganic & Medicinal Chemistry Letters 21 (2011) 4498–4502es_ES
dc.identifier.issn0960-894X-
dc.identifier.urihttps://hdl.handle.net/10171/61120-
dc.description.abstractContinuing with the efforts to identify new active compounds against malaria and leishmaniasis, fourteen new 3-amino-1,4-di-N-oxide quinoxaline-2-carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum Colombian FCR-3 strain and Leishmania amazonensis strain MHOM/BR/76/LTB-012A. Further computational studies to analyze graphic SAR and ADME properties were undertaken. Results indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were foundes_ES
dc.language.isospaes_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectQuinoxalinees_ES
dc.subjectN-oxideses_ES
dc.subjectMalariaes_ES
dc.subjectLeishmaniasises_ES
dc.titleNew salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activitieses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThe authors gratefully acknowledge the ‘‘Oficina de Cooperación de la Embajada de Bélgica” for funding a Master Scholarship to Denis Castillo. Carlos Barea is indebted to the University of Navarra (Spain) for PhD scholarshipes_ES
dc.editorial.noteCC BY-NC-NDes_ES
dc.identifier.doi10.1016/j.bmcl.2011.05.125-

Files in This Item:
Thumbnail
File
ManuscriptBMCL2011.pdf
Description
Size
152.87 kB
Format
Adobe PDF


Statistics and impact

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.