Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Barea, C. (Carlos) | - |
dc.creator | Pabon, A. (Adriana) | - |
dc.creator | Castillo, D. (Denis) | - |
dc.creator | Zimic, M. (Mirko) | - |
dc.creator | Galiano, S. (Silvia) | - |
dc.creator | Pérez-Silanes, S. (Silvia) | - |
dc.creator | Monge, A. (Antonio) | - |
dc.creator | Deharo, E. (Eric) | - |
dc.creator | Aldana, I. (Ignacio) | - |
dc.date.accessioned | 2021-07-23T11:45:11Z | - |
dc.date.available | 2021-07-23T11:45:11Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Bioorganic & Medicinal Chemistry Letters 21 (2011) 4498–4502 | es_ES |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://hdl.handle.net/10171/61120 | - |
dc.description.abstract | Continuing with the efforts to identify new active compounds against malaria and leishmaniasis, fourteen new 3-amino-1,4-di-N-oxide quinoxaline-2-carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum Colombian FCR-3 strain and Leishmania amazonensis strain MHOM/BR/76/LTB-012A. Further computational studies to analyze graphic SAR and ADME properties were undertaken. Results indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were found | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Quinoxaline | es_ES |
dc.subject | N-oxides | es_ES |
dc.subject | Malaria | es_ES |
dc.subject | Leishmaniasis | es_ES |
dc.title | New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | The authors gratefully acknowledge the ‘‘Oficina de Cooperación de la Embajada de Bélgica” for funding a Master Scholarship to Denis Castillo. Carlos Barea is indebted to the University of Navarra (Spain) for PhD scholarship | es_ES |
dc.editorial.note | CC BY-NC-ND | es_ES |
dc.identifier.doi | 10.1016/j.bmcl.2011.05.125 | - |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.