Rev1 wbdR tagged vaccines against Brucella ovis
Keywords: 
Materias Investigacion::Ciencias de la vida::Inmunología
Issue Date: 
2019
Publisher: 
Springer Science and Business Media LLC
ISSN: 
0928-4249
Note: 
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Citation: 
Aragón-Aranda, B. (Beatriz); Miguel, M.J. (María Jesús) de; Martinez-Gomez, E. (Estrella); et al. "Rev1 wbdR tagged vaccines against Brucella ovis". Veterinary Research. 50 (95), 2019, 1 - 9
Abstract
Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyltransferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be diferentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.

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