Materias Investigacion::Ciencias de la vida::Inmunología
Springer Science and Business Media LLC
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Aragón-Aranda, B. (Beatriz); Miguel, M.J. (María Jesús) de; Martinez-Gomez, E. (Estrella); et al. "Rev1 wbdR tagged vaccines against Brucella ovis". Veterinary Research. 50 (95), 2019, 1 - 9
Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyltransferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be diferentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.