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dc.creatorRuiz-Gaton, L. (Luisa)-
dc.creatorEspuelas, S. (Socorro)-
dc.creatorHuarte, J. (Judit)-
dc.creatorLarrañeta, E. (Eneko)-
dc.creatorMartin-Arbella, N. (Nekane)-
dc.creatorIrache, J.M. (Juan Manuel)-
dc.date.accessioned2021-09-09T11:44:22Z-
dc.date.available2021-09-09T11:44:22Z-
dc.date.issued2019-
dc.identifier.citationRuiz-Gaton, L. (Luisa); Espuelas, S. (Socorro); Huarte, J. (Judit); et al. "Nanoparticles from Gantrez® AN-poly(ethylene glycol) conjugates as carriers for oral delivery of docetaxel". International Journal of Pharmaceutics. 571, 2019, 118699es_ES
dc.identifier.issn0378-5173-
dc.identifier.otherPMID: 31536764-
dc.identifier.urihttps://hdl.handle.net/10171/61972-
dc.description.abstractThe oral delivery of docetaxel (DTX) is challenging due to a low bioavailability, related to an important pre-systemic metabolism. With the aim of improving the bioavailability of this cytotoxic agent, nanoparticles from conjugates based on the copolymer of methyl vinyl ether and maleic anhydride (poly(anhydride)) and two different types of PEG, PEG2000 (PEG2) or methoxyPEG2000 (mPEG2), were evaluated. Nanoparticles, with a DTX loading close to 10%, were prepared by desolvation and stabilized with calcium, before purification and lyophilization. For the pharmacokinetic study, nanoparticles were orally administered to mice at a single dose of 30 mg/kg. The plasma levels of DTX were high, prolonged in time and, importantly, quantified within the therapeutic window. The relative oral bioavailability was calculated to be up to 56% when DTX was loaded in nanoparticles from poly(anhydride)-mPEG2000 conjugate (DTX-NP-mPEG2). Finally, a comparative toxicity study between equitoxic doses of free iv DTX and oral DTX-NP-mPEG2 was conducted in mice. Animals orally treated with DTX-loaded nanoparticles displayed less severe signs of hypersensitivity reactions, peripheral neurotoxicity, myelosuppression and hepatotoxicity than free iv docetaxel. In summary, poly(anhydride)-PEG conjugate nanoparticles appears to be adequate carries for the oral delivery of docetaxel.es_ES
dc.description.sponsorshipThis work was supported by grants from “Caja de Ahorros de Navarra” (CAN) project “Nanotecnología y medicamentos” (ref 10828) and by the Spanish Ministry of Science and Innovation (project SAF2008-02538). Luisa Ruiz-Gatón was also financially supported by a grant from “Asociación de Amigos Universidad de Navarra” (ADA).es_ES
dc.language.isoenges_ES
dc.publisherElsevier BVes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectMaterias Investigacion::Farmacia::Química farmacéuticaes_ES
dc.subjectBioavailabilityes_ES
dc.subjectConjugateses_ES
dc.subjectDocetaxeles_ES
dc.subjectNanoparticleses_ES
dc.subjectOral deliveryes_ES
dc.subjectPoly(ethylene glycol)es_ES
dc.titleNanoparticles from Gantrez® AN-poly(ethylene glycol) conjugates as carriers for oral delivery of docetaxeles_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversion10.1016/j.ijpharm.2019.118699es_ES
dc.description.noteThis manuscript is distributed under a Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are citedes_ES
dc.identifier.doi10.1016/j.ijpharm.2019.118699-
dadun.citation.publicationNameInternational Journal of Pharmaceuticses_ES
dadun.citation.startingPage118699es_ES
dadun.citation.volume571es_ES

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