Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Carrasco-León, A. (Arantxa) | - |
dc.creator | Amundarain, A. (Ane) | - |
dc.creator | Gómez-Echarte, N. (Nahia) | - |
dc.creator | Prosper-Cardoso, F. (Felipe) | - |
dc.creator | Agirre-Ena, X. (Xabier) | - |
dc.date.accessioned | 2021-09-14T06:58:22Z | - |
dc.date.available | 2021-09-14T06:58:22Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Carrasco-Leon, A. (Arantxa); Amundarain, A.; Gómez-Echarte, N. (Nahia); et al. "The Role of lncRNAs in the Pathobiology and Clinical Behavior of Multiple Myeloma". Cancers. 13 (8), 2021, 1976 | es |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | https://hdl.handle.net/10171/61990 | - |
dc.description.abstract | Simple Summary Multiple myeloma (MM), the second most common hematological neoplasm, is still considered an incurable disease. Long non-coding RNAs (lncRNAs), genes that do not encode proteins, participate in numerous biological processes, but their deregulation, like that of coding genes, can contribute to carcinogenesis. Increasing evidence points to the relevant role of lncRNAs in the development of human tumors, such that they emerge as attractive biomarkers and therapeutic targets for cancer treatment, including MM. Here we review the oncogenic or tumor-suppressor functions of lncRNAs in MM and provide an overview of novel therapeutic approaches based on lncRNAs that will help to improve the management of these patients. MM is a hematological neoplasm that is still considered an incurable disease. Besides established genetic alterations, recent studies have shown that MM pathogenesis is also characterized by epigenetic aberrations, such as the gain of de novo active chromatin marks in promoter and enhancer regions and extensive DNA hypomethylation of intergenic regions, highlighting the relevance of these non-coding genomic regions. A recent study described how long non-coding RNAs (lncRNAs) correspond to 82% of the MM transcriptome and an increasing number of studies have demonstrated the importance of deregulation of lncRNAs in MM. In this review we focus on the deregulated lncRNAs in MM, including their biological or functional mechanisms, their role as biomarkers to improve the prognosis and monitoring of MM patients, and their participation in drug resistance. Furthermore, we also discuss the evidence supporting the role of lncRNAs as therapeutic targets through different novel RNA-based strategies. | - |
dc.description.sponsorship | This study was funded by grants from Instituto de Salud Carlos III (ISCIII) and co-financed by FEDER: PI17/00701, PI19/01352 and CIBERONC CB16/12/00489, with support from 616/C/2019 Fundació La Marató de TV3, Cancer Research UK [C355/A26819] and FC AECC and AIRC under the Accelerator Award Programme, the Multiple Myeloma Research Foundation Networks of Excellence 2017 Immunotherapy Program Grant Award, the International Myeloma Foundation (Brian van Novis), the Qatar National Research Fund award 7-916-3-237 and Paula and Rodger Riney Foundation. A.C-L. was supported by the ISCIII and FSE (FI16/00275) awards from ISCIII, A.A. by an FPU (FPU17/02733) grant from Ministerio de Ciencia, Innovación y Universidades, Gobierno de España, and N.G-E. by the Ayudas Predoctorales de Investigación Biomédica AC from FIMA. | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | lncRNAs | - |
dc.subject | Multiple myeloma | - |
dc.subject | RNA-based therapy | - |
dc.title | The Role of lncRNAs in the Pathobiology and Clinical Behavior of Multiple Myeloma | - |
dc.type | info:eu-repo/semantics/review | - |
dc.description.note | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) | - |
dc.identifier.doi | 10.3390/cancers13081976 | - |
dadun.citation.number | 8 | - |
dadun.citation.publicationName | Cancers | - |
dadun.citation.startingPage | 1976 | - |
dadun.citation.volume | 13 | - |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.