New emerging targets in cancer immunotherapy: CD137/4-1BB costimulatory axis
Keywords: 
CD137
4-1BB
Cancer immunotherapy
mAb
Issue Date: 
2019
ISSN: 
2059-7029
Note: 
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY- NC 4.0) license
Citation: 
Etxeberria-Uriz, I. (Iñaki); González-Vaz, F. (Francisco Javier); Teijeira-Sánchez, Á. (Álvaro); et al. "New emerging targets in cancer immunotherapy: CD137/4-1BB costimulatory axis". ESMO Open. 4 (Supl. 3), 2019, e000733
Abstract
CD137 (4-1BB) is a surface glycoprotein that belongs to the tumour necrosis factor receptor family (TNFRSF9). Its expression is induced on activation on a number of leucocyte types. Interestingly, for cancer immunotherapy, CD137 becomes expressed on primed T and natural killer (NK) cells, which on ligation provides powerful costimulatory signals. Perturbation of CD137 by CD137L or agonist monoclonal antibodies on activated CD8 T cells protects such antigen-specific cytotoxic T lymphocytes from apoptosis, enhances effector functionalities and favours persistence and memory differentiation. As a consequence, agonist antibodies exert potent antitumour effects in mouse models and the CD137 signalling domain is critical in chimeric antigen receptors (CAR) of CAR T cells approved to be used in the clinic. New formats of CD137 agonist moieties are being clinically developed, seeking potent costimulation targeted to the tumour microenvironment to avoid liver inflammation side effects, that have thus far limited and delayed clinical development.

Files in This Item:
Thumbnail
File
pdf.pdf
Description
Size
986.03 kB
Format
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.