Combining Gene Transfer and Nonhuman Primates to Better Understand and Treat Parkinson’s Disease
Keywords: 
Materias Investigacion::Ciencias de la Salud::Neurología
Parkinson’s disease
Primate
CAV vectors
Gene transfer
Dopaminergic neurons
Issue Date: 
2019
Publisher: 
Frontiers Media SA
ISSN: 
1662-5099
Note: 
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Citation: 
Lasbleiz, C. (Christelle); Mestre-Francés, N. (Nadine); Devau, G. (Gina); et al. "Combining Gene Transfer and Nonhuman Primates to Better Understand and Treat Parkinson’s Disease". Frontiers in Molecular Neuroscience. 12 (10), 2019, 1 - 8
Abstract
Parkinson's disease (PD) is a progressive CNS disorder that is primarily associated with impaired movement. PD develops over decades and is linked to the gradual loss of dopamine delivery to the striatum, via the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). While the administration of L-dopa and deep brain stimulation are potent therapies, their costs, side effects and gradual loss of efficacy underlines the need to develop other approaches. Unfortunately, the lack of pertinent animal models that reproduce DA neuron loss and behavior deficits-in a timeline that mimics PD progression-has hindered the identification of alternative therapies. A complementary approach to transgenic animals is the use of nonhuman primates (NHPs) combined with the overexpression of disease-related genes using viral vectors. This approach may induce phenotypes that are not influenced by developmental compensation mechanisms, and that take into account the personality of animals. In this review article, we discuss the combination of gene transfer and NHPs to develop "genetic" models of PD that are suitable for testing therapeutic approaches.

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