Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Frühbeck, G. (Gema) | - |
dc.creator | Catalan, V. (Victoria) | - |
dc.creator | Rodriguez, A. (Amaia) | - |
dc.creator | Ramirez, B. (Beatriz) | - |
dc.creator | Becerril, S. (Sara) | - |
dc.creator | Salvador, J. (Javier) | - |
dc.creator | Colina, I. (Inmaculada) | - |
dc.creator | Gomez-Ambrosi, J. (Javier) | - |
dc.date.accessioned | 2021-09-20T09:52:42Z | - |
dc.date.available | 2021-09-20T09:52:42Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Frühbeck, G. (Gema); Catalan, V. (Victoria); Rodriguez, A. (Amaia); et al. "Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation". Nutrients. 11 (454), 2019, 1 - 13 | es |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.other | PMID: 30813240 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62033 | - |
dc.description.abstract | Obesity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D) and the metabolic syndrome (MS). Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin. Consequently, the Adpn/Lep ratio has been suggested as a maker of dysfunctional adipose tissue. We aimed to investigate in humans (n = 292) the reliability of the Adpn/Lep ratio as a biomarker of adipose tissue dysfunction. We considered that an Adpn/Lep ratio of ≥1.0 can be considered normal, a ratio of ≥0.5 <1.0 suggests moderate-medium increased risk, and a ratio of <0.5 indicates a severe increase in cardiometabolic risk. Using these cut-offs, 5%, 54% and 48% of the lean, normoglycemic and without-MS subjects, respectively, fall within the group with an Adpn/Lep ratio below 0.5; while 89%, 86% and 90% of the obese, with T2D and with MS patients fall within the same group (p < 0.001). A significant negative correlation (r = -0.21, p = 0.005) between the Adpn/Lep ratio and serum amyloid A (SAA) concentrations, a marker of adipose tissue dysfunction, was found. We concluded that the Adpn/Lep ratio is a good indicator of a dysfunctional adipose tissue that may be a useful estimator of obesity- and MS-associated cardiometabolic risk, allowing the identification of a higher number of subjects at risk. | es_ES |
dc.description.sponsorship | This work was supported by Plan Estatal I+D+I from the Spanish Instituto de Salud Carlos III–Subdirección General de Evaluación y Fomento de la investigación–FEDER (grants number PI16/01217, PI17/02183 and PI17/02188), and by CIBEROBN, ISCIII, Spain. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Endocrinología | es_ES |
dc.subject | Adiponectin/leptin ratio | es_ES |
dc.subject | Adipose tissue | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | Metabolic syndrome | es_ES |
dc.subject | Obesity | es_ES |
dc.subject | Type 2 diabetes | es_ES |
dc.title | Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.identifier.doi | 10.3390/nu11020454 | - |
dadun.citation.endingPage | 13 | es_ES |
dadun.citation.number | 454 | es_ES |
dadun.citation.publicationName | Nutrients | es_ES |
dadun.citation.startingPage | 1 | es_ES |
dadun.citation.volume | 11 | es_ES |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.