Galectin-3 inhibition with modified citrus pectin in hypertension
Keywords: 
Cardiac fibrosis
Galectin-3
Heart failure
Issue Date: 
2021
ISSN: 
2452-302X
Note: 
This is an open access article under the CC BY-NC-ND license
Citation: 
Lau, E. S.; Liu, E.; Paniagua, S. M.; et al. "Galectin-3 inhibition with modified citrus pectin in hypertension". JACC: Basic to Translational Science. 6 (1), 2021, 12 - 21
Abstract
We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, treatment with modified citrus pectin did not change collagen markers. The effect of Gal-3 inhibition among individuals with heart failure warrants further investigation. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

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