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dc.creatorStratakis, N. (Nikos)-
dc.creatorGolden-Mason, L. (Lucy)-
dc.creatorMargetaki, K. (Katerina)-
dc.creatorZhao, Y. (Yinqi)-
dc.creatorValvi, D. (Damaskini)-
dc.creatorGarcía, E. (Erika)-
dc.creatorMaitre, L. (Léa)-
dc.creatorAndrusaityte, S. (Sandra)-
dc.creatorBasagana, X. (Xavier)-
dc.creatorBorrás, E. (Eva)-
dc.creatorBustamante, M. (Mariona)-
dc.creatorCasas, M. (Maribel)-
dc.creatorFossati, S. (Serena)-
dc.creatorGrazuleviciene, R. (Regina)-
dc.creatorHaug, L.S. (Line Smastuen)-
dc.creatorHeude, B. (Barbara)-
dc.creatorMcEachan, R.R.C. (Rosemary R. C.)-
dc.creatorMeltzer, H.M. (Helle Margrete)-
dc.creatorPapadopoulou, E. (Eleni)-
dc.creatorRoumeliotaki, T. (Theano)-
dc.creatorRobinson, O. (Oliver)-
dc.creatorSabidó, E. (Eduard)-
dc.creatorUrquiza, J. (Jose)-
dc.creatorVafeiadi, M. (Marina)-
dc.creatorVaro-Cenarruzabeitia, M. N. (Miren Nerea)-
dc.creatorWright, J. (John)-
dc.creatorVos, M.B. (Miriam B.)-
dc.creatorHu, H. (Howard)-
dc.creatorVrijheid, M. (Martine)-
dc.creatorBerhane, K.T. (Kiros T.)-
dc.creatorConti, D.V. (David V.)-
dc.creatorMcConnell, R. (Rob)-
dc.creatorRosen, H.R. (Hugo R.)-
dc.creatorChatzi, L. (Lida)-
dc.identifier.citationStratakis, N.; Golden-Mason, L.; Margetaki, K.; et al. "In Utero exposure to mercury is associated with increased susceptibility to liver injury and inflammation in childhood". Hepatology. 74 (3), 2021, 1546 - 1559es
dc.description.abstractBackground and Aims Nonalcoholic fatty liver disease (NAFLD) is the most prevalent cause of liver disease in children. Mercury (Hg), a ubiquitous toxic metal, has been proposed as an environmental factor contributing to toxicant-associated fatty liver disease. Approach and Results We investigated the effect of prenatal exposure to Hg on childhood liver injury by combining epidemiological results from a multicenter mother-child cohort with complementary in vitro experiments on monocyte cells that are known to play a key role in liver immune homeostasis and NAFLD. We used data from 872 mothers and their children (median age, 8.1 years; interquartile range [IQR], 6.5-8.7) from the European Human Early-Life Exposome cohort. We measured Hg concentration in maternal blood during pregnancy (median, 2.0 mu g/L; IQR, 1.1-3.6). We also assessed serum levels of alanine aminotransferase (ALT), a common screening tool for pediatric NAFLD, and plasma concentrations of inflammation-related cytokines in children. We found that prenatal Hg exposure was associated with a phenotype in children that was characterized by elevated ALT (>= 22.1 U/L for females and >= 25.8 U/L for males) and increased concentrations of circulating IL-1 beta, IL-6, IL-8, and TNF-alpha.-
dc.description.sponsorshipSupported by the National Institute of Environmental Health Sciences (R21ES029681; R01ES030691, R01ES029944, R01ES030364, R21ES028903, and P30ES007048, to L.C.; R01ES030691, R01ES030364, R21ES028903, and P30ES007048, to R.M.; R01ES030691, R01ES029944, R01ES030364, and P30ES007048, to D.V.C.; R01ES030691, R01ES029944, R01ES030364, and R21ES028903, to D.V.; R01ES030364, to N.S.; and P30ES007048, to E.G), the National Institutes of Health (P01CA196569 and R01CA140561, to D.V.C.; P30DK048522, to N.S.), the Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128, to M.C.), and the Juan de la Cierva-Incorporación fellowship (IJC2018-035394-I, to L.M.), awarded by the Spanish Ministerio de Economía, Industria y Competitividad. The Human Early Life Exposome project was supported by the European Community’s Seventh Framework Programme (FP7/2007-2013, under grant 30833). INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya-CIRIT. The KANC cohort was supported by the Lithuanian Agency for Science Innovation and Technology (31V-77). For a full list of funding that supported the EDEN cohort, see https://doi.org/10.1093/ije/dyv151. The Norwegian Mother, Father and Child Cohort Study was supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research. The Rhea cohort was supported by European projects; the Greek Ministry of Health (Program of Prevention of Obesity and Neurodevelopmental Disorders in Preschool Children, in Heraklion district, Crete, Greece), 2011-2014; and Rhea Plus: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-2015. The BiB cohort was supported by a Wellcome Trust infrastructure grant (WT101597MA). R.R.C.M. and J.W. received funding from the National Institute for Health Research Applied Research Collaboration for Yorkshire and Humber. The CRG/UPF Proteomics Unit is part of the Spanish Infrastructure for Omics Technologies (ICTS OmicsTech) and a member of the ProteoRed PRB3 consortium, which is supported by grant PT17/0019 of the PE I + D+i 2013-2016 from the Instituto de Salud Carlos III and European Regional Development Fund. This study was further supported by grants from the Spanish Ministry of Science, Innovation and Universities, Centro de Excelencia Severo Ochoa 2013-2017 (SEV-2012-0208), and Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya (2017SGR595).-
dc.subjectÁrea de Biomedicina-
dc.titleIn utero exposure to mercury is associated with increased susceptibility to liver injury and inflammation in childhood-

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