Full metadata record
DC Field | Value | Language |
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dc.creator | López, B. (Beatriz) | - |
dc.creator | Alvarez-Erviti, L. (Lydia) | - |
dc.creator | De-Santis, B. (Barbara) | - |
dc.creator | Izco, M. (María) | - |
dc.creator | López-Calvo, S. (Silvia) | - |
dc.creator | Marzo-Sola, M.E. (María Eugenia) | - |
dc.creator | Debegnach, F. (Francesca) | - |
dc.creator | Lizarraga, E. (Elena) | - |
dc.creator | Lopez-de-Cerain, A. (Adela) | - |
dc.creator | Gonzalez-Peñas, E. (Elena) | - |
dc.creator | Vettorazzi, A. (Ariane) | - |
dc.date.accessioned | 2021-10-04T12:14:38Z | - |
dc.date.available | 2021-10-04T12:14:38Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Arce-Lopez, B.; Alvarez-Erviti, L.; De Santis, B.; et al. "Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer's and Parkinson's Disease". Toxins. 13 (7), 2021, 477 | es |
dc.identifier.issn | 2072-6651 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62145 | - |
dc.description.abstract | Exposure to environmental contaminants might play an important role in neurodegenerative disease pathogenesis, such as Parkinson ' s disease (PD) and Alzheimer's disease (AD). For the first time in Spain, the plasmatic levels of 19 mycotoxins from patients diagnosed with a neurodegenerative disease (44 PD and 24 AD) and from their healthy companions (25) from La Rioja region were analyzed. The studied mycotoxins were aflatoxins B1, B2, G1, G2 and M1, T-2 and HT-2, ochratoxins A (OTA) and B (OTB), zearalenone, sterigmatocystin (STER), nivalenol, deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, deepoxy-deoxynivalenol, neosolaniol, diacetoxyscirpenol and fusarenon-X. Samples were analyzed by LC-MS/MS before and after treatment with beta-glucuronidase/arylsulfatase in order to detect potential metabolites. Only OTA, OTB and STER were detected in the samples. OTA was present before (77% of the samples) and after (89%) the enzymatic treatment, while OTB was only detectable before (13%). Statistically significant differences in OTA between healthy companions and patients were observed but the observed differences might seem more related to gender (OTA levels higher in men, p-value = 0.0014) than the disease itself. STER appeared only after enzymatic treatment (88%). Statistical analysis on STER, showed distributions always different between healthy controls and patients (patients' group > controls, p-value < 0.0001). Surprisingly, STER levels weakly correlated positively with age in women (rho = 0.3384), while OTA correlation showed a decrease of levels with age especially in the men with PD (rho = -0.4643). | - |
dc.description.sponsorship | This work was funded by the Spanish “Ministerio de Economía, Industria y Competitivi- dad, Agencia Estatal de Investigación” (AGL2017-85732-R) (MINECO/AEI/FEDER, UE) and by the Government of Navarra (Project-43, 2019 modality A) and European Regional Development Fund (ERDF under Operational Programme for Navarra 2014–2020). LAE is supported by a Miguel Servet II contract (CPII20/00027) from ISCIII. | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Mycotoxins | - |
dc.subject | Ochratoxin A | - |
dc.subject | Sterigmatocystin | - |
dc.subject | Human exposure | - |
dc.subject | Parkinson's disease | - |
dc.subject | Alzheimer's disease | - |
dc.subject | Neurodegenerative disease | - |
dc.title | Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer's and Parkinson's Disease | - |
dc.type | info:eu-repo/semantics/article | - |
dc.description.note | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
dc.identifier.doi | 10.3390/toxins13070477 | - |
dadun.citation.number | 7 | - |
dadun.citation.publicationName | Toxins | - |
dadun.citation.startingPage | 477 | - |
dadun.citation.volume | 13 | - |
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