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dc.creatorIzaguirre, M. (Maitane)-
dc.creatorGomez-Ambrosi, J. (Javier)-
dc.creatorRodriguez, A. (Amaia)-
dc.creatorRamirez, B. (Beatriz)-
dc.creatorBecerril, S. (Sara)-
dc.creatorValenti, V. (Víctor)-
dc.creatorMoncada, R. (Rafael)-
dc.creatorUnamuno, X. (Xabier)-
dc.creatorSilva, C. (Camilo)-
dc.creatorHiguera, M. (Magdalena) de la-
dc.creatorSalvador, J. (Javier)-
dc.creatorMonreal, J.I. (José Ignacio)-
dc.creatorFrühbeck, G. (Gema)-
dc.creatorCatalan, V. (Victoria)-
dc.identifier.citationIzaguirre, M. (Maitane); Gomez-Ambrosi, J. (Javier); Rodriguez, A. (Amaia); et al. "GLP-1 limits adipocyte inflammation and its low circulating pre-operative concentrations predict worse type 2 diabetes remission after bariatric surgery in obese patients". Journal of Clinical Medicine. 8 (4), 2019, 479es_ES
dc.description.abstractObjective: Glucagon-like peptide (GLP)-1 has been proposed as a key candidate in glucose improvements after bariatric surgery. Our aim was to explore the role of GLP-1 in surgically-induced type 2 diabetes (T2D) improvement and its capacity to regulate human adipocyte inflammation. Methods: Basal circulating concentrations of GLP-1 as well as during an oral glucose tolerance test (OGTT) were measured in lean and obese volunteers with and without T2D (n = 93). In addition, GLP-1 levels were determined before and after weight loss achieved by Roux-en-Y gastric bypass (RYGB) (n = 77). The impact of GLP-1 on inflammation signalling pathways was also evaluated. Results: We show that the reduced (p < 0.05) circulating levels of GLP-1 in obese T2D patients increased (p < 0.05) after RYGB. The area under the curve was significantly lower in obese patients with (p < 0.01) and without (p < 0.05) T2D compared to lean volunteers while obese patients with T2D exhibited decreased GLP-1 levels at baseline (p < 0.05) and 120 min (p < 0.01) after the OGTT. Importantly, higher (p < 0.05) pre-operative GLP-1 concentrations were found in patients with T2D remission after RYGB. We also revealed that exendin-4, a GLP-1 agonist, downregulated the expression of inflammation-related genes (IL1B, IL6, IL8, TNF) and, conversely, upregulated the mRNA levels of ADIPOQ in human visceral adipocytes. Furthermore, exendin-4 blocked (p < 0.05) LPS-induced inflammation in human adipocytes via downregulating the expression and secretion of key inflammatory markers. Conclusions: Our data indicate that GLP-1 may contribute to glycemic control and exert a role in T2D remission after RYGB. GLP-1 is also involved in limiting inflammation in human visceral adipocytes.es_ES
dc.description.sponsorshipThis work was supported by ISCIII-Subdirección General de Evaluación y FEDER (PI16/01217, PI17/02183 and PI17/02188; Plan Estatal I + D + I) and by the Gobierno de Navarra (10/2018). CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) is an initiative of the ISCIII, Spaines_ES
dc.publisherMDPI AGes_ES
dc.subjectAdipose tissuees_ES
dc.subjectBariatric surgeryes_ES
dc.subjectT2D remissiones_ES
dc.titleGLP-1 limits adipocyte inflammation and its low circulating pre-operative concentrations predict worse type 2 diabetes remission after bariatric surgery in obese patientses_ES
dc.description.noteThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedes_ES
dadun.citation.publicationNameJournal of Clinical Medicinees_ES

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