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dc.creatorBerraondo, P. (Pedro)-
dc.date.accessioned2021-10-27T07:03:40Z-
dc.date.available2021-10-27T07:03:40Z-
dc.date.issued2019-
dc.identifier.citationBerraondo, P. (Pedro). "Mechanisms of action for different checkpoint inhibitors". HemaSphere. 3 (S2), 2019, 28 - 30es_ES
dc.identifier.issn2572-9241-
dc.identifier.urihttps://hdl.handle.net/10171/62281-
dc.description.abstractThe immune system is composed of a complex network of cells and soluble factors. This network is specialized in detecting dangerous homeostatic alterations. Once a dangerous alteration is detected, the immune network initiates an immune response to re-establish the homeostasis. Co-inhibitory receptors control the activation and the intensity of the adaptive immune response and therefore, they function as immune checkpoints. The activity of the immune checkpoints is crucial to avoid exacerbated immune responses and autoimmunity by induction of T lymphocyte exhaustion. This process is mainly induced by the chronic exposure to the antigen and is characterized by (i) the progressive loss of the production of proinflammatory cytokines such as tumor necrosis factor alpha and interferon gamma, (ii) the loss of the cytotoxic activity, (iii) the decrease in the proliferative potential and (iv) an increase in apoptosis. Exhaustion is a progressive process that can finally lead to the clonal deletion of T lymphocytes with high-affinity T cell receptor (TCR). The T lymphocytes express progressively co-inhibitory receptors such as PD-1, LAG-3, and TIM-3. This process also involves an epigenetic remodeling that marks a point of terminal exhaustion.es_ES
dc.language.isoenges_ES
dc.publisherWolters Kluwer Healthes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectImmune systemes_ES
dc.subjectHomeostatic alterationses_ES
dc.subjectT lymphocyteses_ES
dc.subjectDangerous alterationes_ES
dc.titleMechanisms of action for different checkpoint inhibitorses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.es_ES
dc.identifier.doi10.1097/HS9.0000000000000244-
dadun.citation.endingPage30es_ES
dadun.citation.numberS2es_ES
dadun.citation.publicationNameHemaSpherees_ES
dadun.citation.startingPage28es_ES
dadun.citation.volume3es_ES

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