Promoter hypermethylation of the AE2/SLC4A2 gene in PBC
Keywords: 
AE2 chloride
Bicarbonate exchanger
Cholestasis
DNA methylation
Epigenetic repression
Primary biliary cholangitis
Cirrhosis
Issue Date: 
2019
Publisher: 
Elsevier
ISSN: 
2589-5559
Note: 
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Citation: 
Arenas, F. (Fabián); Hervias, I. (Isabel); Saez, E. (Elena); et al. "Promoter hypermethylation of the AE2/SLC4A2 gene in PBC". JHEP Reports. 1 (3), 2019, 145 - 153
Abstract
Primary biliary cholangitis (PBC) is a chronic immuneassociated cholestatic liver disease with unclear complex/multifactorial etiopathogenesis affecting mostly middle-aged women. Patients with PBC exhibit reduced expression of the AE2/SLC4A2 gene. Herein, we found that AE2 promoter regions are hypermethylated in the liver and peripheral blood mononuclear cells of patients with PBC. This increased methylation is associated with downregulated AE2-gene expression, which might contribute to the pathogenesis of PBC. Therefore, novel epigenetic targets may improve treatment in patients with PBC who respond poorly to current pharmacological therapies.

Files in This Item:
Thumbnail
File
PIIS2589555919300540.pdf
Description
Size
1.36 MB
Format
Adobe PDF


Statistics and impact

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.