Stereotactic radiosurgery for the treatment of recurrent high-grade gliomas: long-term follow-up
Keywords: 
Radiosurgery
Cyberknife®
Recurrent gliomas
Ck-cyberknife
Glioblastoma multiforme (gbm)
Recurrent gbm
Srs
Issue Date: 
2019
Publisher: 
Cureus, Inc.
ISSN: 
2168-8184
Note: 
This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation: 
Sallabanda, K. (Kita); Yañez, L. (Loreto); Sallabanda, M. (Morena); et al. "Stereotactic radiosurgery for the treatment of recurrent high-grade gliomas: long-term follow-up". Cureus. 11 (12), 2019, e6527
Abstract
High-grade gliomas (HGG) are the most frequent primary central nervous system tumors; treatment of HCGs includes surgery and post-operative conformal radiotherapy associated with temozolomide (TMZ or procarbazine/lomustine/vincristine [PCV], specifically in patients with anaplastic oligodendrogliomas or anaplastic oligoastrocytomas). However, recurrence is common. Re-irradiation has been utilized in this setting for years and remains a feasible option, although there is always a concern regarding toxicity. Modern high-precision conformal techniques, including stereotactic radiosurgery (SRS), could improve the therapeutic ratio by delivering high biologically equivalent doses while reducing high-dose radiotherapy (RT) to normal brain tissue. In this paper, we present the results obtained after prolonged follow-up in patients who underwent SRS as a treatment for recurrent high-grade gliomas at San Francisco Hospital in Madrid, Spain.

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