Full metadata record
DC Field | Value | Language |
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dc.creator | Molina-Vega, M. (María) | - |
dc.creator | Rodríguez-Pérez, C.A. (Carlos Antonio) | - |
dc.creator | Álvarez-Mancha, A.I. (Ana Isabel) | - |
dc.creator | Baena-Nieto, G. (Gloria) | - |
dc.creator | Riestra, M. (María) | - |
dc.creator | Alcázar, V. (Victoria) | - |
dc.creator | Romero-Lluch, A.R. (Ana Reyes) | - |
dc.creator | Galofre, J.C. (Juan Carlos) | - |
dc.creator | Fernandez-Garcia, J.C. (José C.) | - |
dc.date.accessioned | 2021-10-27T09:38:27Z | - |
dc.date.available | 2021-10-27T09:38:27Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Molina-Vega, M. (María); Rodríguez-Pérez, C.A. (Carlos Antonio); Álvarez-Mancha, A.I. (Ana Isabel); et al. "Clinical and ultrasound thyroid nodule characteristics and their association with cytological and histopathological outcomes: A retrospective multicenter study in high-resolution thyroid nodule clinics". Journal of Clinical Medicine. 8 (12), 2019, 2172 | es_ES |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62287 | - |
dc.description.abstract | Introduction: Thyroid nodules are a common finding. A high-resolution thyroid nodule clinic (HR-TNC) condenses all tests required for the evaluation of thyroid nodules into a single appointment. We aimed to evaluate the clinical outcomes at HR-TNCs. Design and Methods: A retrospective cross-sectional multicenter study including data from four HR-TNCs in Spain. We evaluated fine-needle aspiration (FNA) indications and the association between clinical and ultrasound characteristics with cytological and histopathological outcomes. Results: A total of 2809 thyroid nodules were included; FNA was performed in 82.1%. Thyroid nodules that underwent FNA were more likely larger, isoechoic, with microcalcifications, and in younger subjects. The rate of nondiagnostic FNA was 4.3%. A solid component, irregular margins or microcalcifications, significantly increased the odds of Bethesda IV-V-VI (vs. Bethesda II). Irregular margins and a solid component were independently associated with increased odds of malignancy. Thyroid nodules <20 mm and ≥20–<40 mm had a 6.5-fold and 3.3-fold increased risk for malignancy respectively in comparison with those ≥40 mm. Conclusion: In this large multicenter study, we found that the presence of a solid component and irregular margins are factors independently related to malignancy in thyroid nodules. Since nodule size ≥40 mm was associated with the lowest odds of malignancy, this cut-off should not be a factor leading to indicate thyroid surgery. HR-TNCs were associated with a low rate of nondiagnostic FNA. | es_ES |
dc.description.sponsorship | This study was supported by the “Centros de Investigación Biomédica en Red” (CIBER) of the Institute of Health Carlos III (ISCIII) (CB06/03/0018) and research grants from the ISCIII (PI18/01160), and co-financed by the European Regional Development Fund (ERDF). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Thyroid nodules | es_ES |
dc.subject | Ultrasound | es_ES |
dc.subject | Fine needle aspiration | es_ES |
dc.title | Clinical and ultrasound thyroid nodule characteristics and their association with cytological and histopathological outcomes: A retrospective multicenter study in high-resolution thyroid nodule clinics | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited | es_ES |
dc.identifier.doi | 10.3390/jcm8122172 | - |
dadun.citation.number | 12 | es_ES |
dadun.citation.publicationName | Journal of Clinical Medicine | es_ES |
dadun.citation.startingPage | 2172 | es_ES |
dadun.citation.volume | 8 | es_ES |
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