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Federico, C. (Cinzia); Sacco, A. (Antonio); Belotti, A. (Angelo); et al. "Circulating microRNAs and their role in multiple myeloma". Non-Coding RNA. 5 (2), 2019, 37
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by bone marrow infiltration
of clonal plasma cells. The recent literature has clearly demonstrated clonal heterogeneity in terms
of both the genomic and transcriptomic signature of the tumor. Of note, novel studies have also
highlighted the importance of the functional cross-talk between the tumor clone and the surrounding
bone marrow milieu, as a relevant player of MM pathogenesis. These findings have certainly
enhanced our understanding of the underlying mechanisms supporting MM pathogenesis and
disease progression. Within the specific field of small non-coding RNA-research, recent studies have
provided evidence for considering microRNAs as a crucial regulator of MM biology and, in this
context, circulating microRNAs have been shown to potentially contribute to prognostic stratification
of MM patients. The present review will summarize the most recent studies within the specific topic
of microRNAs and circulating microRNAs in MM.