Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Karagöz, G.E. (Gulsun Elif) | - |
dc.creator | Aragón-Amonárriz, T. (Tomás) | - |
dc.creator | Acosta-Alvear, D. (Diego) | - |
dc.date.accessioned | 2021-11-03T10:02:16Z | - |
dc.date.available | 2021-11-03T10:02:16Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Karagöz, G.E. (Gulsun Elif); Aragón-Amonárriz, T. (Tomás); Acosta-Alvear, D. (Diego). "Recent advances in signal integration mechanisms in the unfolded protein response [version 1; peer review: 2 approved]". F1000Research. 8, 2019, 1840 | es_ES |
dc.identifier.issn | 2046-1402 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62303 | - |
dc.description.abstract | Since its discovery more than 25 years ago, great progress has been made in our understanding of the unfolded protein response (UPR), a homeostatic mechanism that adjusts endoplasmic reticulum (ER) function to satisfy the physiological demands of the cell. However, if ER homeostasis is unattainable, the UPR switches to drive cell death to remove defective cells in an effort to protect the health of the organism. This functional dichotomy places the UPR at the crossroads of the adaptation versus apoptosis decision. Here, we focus on new developments in UPR signaling mechanisms, in the interconnectivity among the signaling pathways that make up the UPR in higher eukaryotes, and in the coordination between the UPR and other fundamental cellular processes. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Taylor & Francis | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | ER stress | es_ES |
dc.subject | Unfolded protein response | es_ES |
dc.subject | Signal transduction pathway interconnectivity | es_ES |
dc.title | Recent advances in signal integration mechanisms in the unfolded protein response [version 1; peer review: 2 approved] | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | es_ES |
dc.identifier.doi | 10.12688/f1000research.19848.1 | - |
dadun.citation.publicationName | F1000Research | es_ES |
dadun.citation.startingPage | 1840 | es_ES |
dadun.citation.volume | 8 | es_ES |
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