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dc.creatorKaragöz, G.E. (Gulsun Elif)-
dc.creatorAragón-Amonárriz, T. (Tomás)-
dc.creatorAcosta-Alvear, D. (Diego)-
dc.date.accessioned2021-11-03T10:02:16Z-
dc.date.available2021-11-03T10:02:16Z-
dc.date.issued2019-
dc.identifier.citationKaragöz, G.E. (Gulsun Elif); Aragón-Amonárriz, T. (Tomás); Acosta-Alvear, D. (Diego). "Recent advances in signal integration mechanisms in the unfolded protein response [version 1; peer review: 2 approved]". F1000Research. 8, 2019, 1840es_ES
dc.identifier.issn2046-1402-
dc.identifier.urihttps://hdl.handle.net/10171/62303-
dc.description.abstractSince its discovery more than 25 years ago, great progress has been made in our understanding of the unfolded protein response (UPR), a homeostatic mechanism that adjusts endoplasmic reticulum (ER) function to satisfy the physiological demands of the cell. However, if ER homeostasis is unattainable, the UPR switches to drive cell death to remove defective cells in an effort to protect the health of the organism. This functional dichotomy places the UPR at the crossroads of the adaptation versus apoptosis decision. Here, we focus on new developments in UPR signaling mechanisms, in the interconnectivity among the signaling pathways that make up the UPR in higher eukaryotes, and in the coordination between the UPR and other fundamental cellular processes.es_ES
dc.language.isoenges_ES
dc.publisherTaylor & Francises_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectER stresses_ES
dc.subjectUnfolded protein responsees_ES
dc.subjectSignal transduction pathway interconnectivityes_ES
dc.titleRecent advances in signal integration mechanisms in the unfolded protein response [version 1; peer review: 2 approved]es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.es_ES
dc.identifier.doi10.12688/f1000research.19848.1-
dadun.citation.publicationNameF1000Researches_ES
dadun.citation.startingPage1840es_ES
dadun.citation.volume8es_ES

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