Complement in metastasis: a comp in the camp
Keywords: 
Cancer
Metastasis
Complement
Tumor microenvironment
Anaphylatoxin
Bone colonization
Issue Date: 
2019
Publisher: 
Frontiers Media SA
ISSN: 
1664-3224
Note: 
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
Citation: 
Ajona, D. (Daniel); Ortiz-Espinosa, S. (Sergio); Pio, R. (Rubén); et al. "Complement in metastasis: a comp in the camp". Frontiers in Immunology. 10, 2019, 669
Abstract
The complement system represents a pillar of the innate immune response. This system, critical for host defense against pathogens, encompasses more than 50 soluble, and membrane-bound proteins. Emerging evidence underscores its clinical relevance in tumor progression and its role in metastasis, one of the hallmarks of cancer. The multistep process of metastasis entails the acquisition of advantageous functions required for the formation of secondary tumors. Thus, targeting components of the complement system could impact not only on tumor initiation but also on several crucial steps along tumor dissemination. This novel vulnerability could be concomitantly exploited with current strategies overcoming tumor-mediated immunosuppression to provide a substantial clinical benefit in the treatment of metastatic disease. In this review, we offer a tour d’horizon on recent advances in this area and their prospective potential for cancer treatment.

Files in This Item:
Thumbnail
File
fimmu-10-00669.pdf
Description
Size
1.21 MB
Format
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.