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dc.creatorMartinez-Velez, N. (Naiara)-
dc.creatorGarcia-Moure, M. (Marc)-
dc.creatorMarigil, M. (Miguel)-
dc.creatorGonzalez-Huarriz, M. (Marisol)-
dc.creatorPuigdelloses-Vallcorba, M. (Montserrat)-
dc.creatorGallego-Perez-Larraya, J. (Jaime)-
dc.creatorZalacain, M. (Marta)-
dc.creatorMarrodán, L. (Lucía)-
dc.creatorVarela-Guruceaga, M. (Maider)-
dc.creatorLaspidea, V. (Virginia)-
dc.creatorAristu-Mendioroz, J. (Javier)-
dc.creatorRamos, L.I. (Luis Isaac)-
dc.creatorTejada-Solis, S. (Sonia)-
dc.creatorDiez-Valle, R. (Ricardo)-
dc.creatorJones, C. (Chris)-
dc.creatorMackay, A. (Alan)-
dc.creatorMartinez-Climent, J.A. (José Ángel)-
dc.creatorGarcía-Barchino, M.J. (María José)-
dc.creatorRaabe, E. (Eric)-
dc.creatorMonje, M. (Michelle)-
dc.creatorBecher, O.J. (Oren J.)-
dc.creatorJunier, M.P. (Marie Pierre)-
dc.creatorEl-Habr, E. (Elías)-
dc.creatorChneiweiss, H. (Hervé)-
dc.creatorAldave, G. (Guillermo)-
dc.creatorJiang, H. (Hong)-
dc.creatorFueyo, J. (Juan)-
dc.creatorPatiño-García, A. (Ana)-
dc.creatorGomez-Manzano, C. (Candelaria)-
dc.creatorAlonso, M. (Marta)-
dc.date.accessioned2021-11-09T11:24:01Z-
dc.date.available2021-11-09T11:24:01Z-
dc.date.issued2019-
dc.identifier.citationMartinez-Velez, N. (Naiara); Garcia-Moure, M. (Marc); Marigil, M. (Miguel); et al. "The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models". Nature Communications. 10 (2235), 2019, 1 - 10es
dc.identifier.issn2041-1723-
dc.identifier.otherPMID: 31138805-
dc.identifier.urihttps://hdl.handle.net/10171/62393-
dc.description.abstractPediatric high-grade glioma (pHGG) and diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors in desperate need of a curative treatment. Oncolytic virotherapy is emerging as a solid therapeutic approach. Delta-24-RGD is a replication competent adenovirus engineered to replicate in tumor cells with an aberrant RB pathway. This virus has proven to be safe and effective in adult gliomas. Here we report that the administration of Delta-24-RGD is safe in mice and results in a significant increase in survival in immunodeficient and immunocompetent models of pHGG and DIPGs. Our results show that the Delta-24-RGD antiglioma effect is mediated by the oncolytic effect and the immune response elicited against the tumor. Altogether, our data highlight the potential of this virus as treatment for patients with these tumors. Of clinical significance, these data have led to the start of a phase I/II clinical trial at our institution for newly diagnosed DIPG (NCT03178032).es_ES
dc.description.sponsorshipThis work was supported by the European Union (Marie Curie IRG270459; to M.M. Alonso), the Instituto de Salud Carlos III y los Fondos Feder Europeos (PI13/125; PI16/0066 to M.M. Alonso), the Spanish Ministry of Science and Innovation (Ramón y Cajal contract RYC-2009–05571, IEDI-2015-00638, and BIO2015-68990-REDT to M.M. Alonso), the Department of Health of the Government of Navarra (to M.M. Alonso), the Basque Foundation for Health Research (BIOEF, BIO13/CI/005), Foundation LA CAIXA/Caja Navarra (A-PG, MMA), Foundation “El sueño de Vicky”, Asociation Pablo Ugarte-Fuerza Julen (A-PG,MMA), and DOD team science award (MMA, JF, and CG-M). The Cancer Prevention and Research Institute of Texas (RP170066; C-GM and JF, the Rory David Deutsch Foundation (OJB) and Instituto de Salud Carlos III—CIBERONC (to JAM-C and MJG-B). This project has received funding from the European Research Council (ERC) under the European Union´s Horizon 2020 research and innovation programme (grant agreement No. 817884; ViroPedTher).es_ES
dc.language.isoenges_ES
dc.publisherSpringer Science and Business Media LLCes_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/817884/EU-
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectMaterias Investigacion::Ciencias de la Salud::Oncologíaes_ES
dc.titleThe oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse modelses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.es_ES
dc.identifier.doi10.1038/s41467-019-10043-0-
dadun.citation.endingPage10es_ES
dadun.citation.number2235es_ES
dadun.citation.publicationNameNature Communicationses_ES
dadun.citation.startingPage1es_ES
dadun.citation.volume10es_ES

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