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dc.creatorMartín-Cardona, A. (A.)-
dc.creatorFernández-Esparrach, G. (G.)-
dc.creatorSubtil, J.C. (José Carlos)-
dc.creatorIglesias-García, J. (J.)-
dc.creatorGarcía-Guix, M. (M.)-
dc.creatorBarturen-Barroso, A. (A.)-
dc.creatorGimeno-García, A.Z. (A. Z.)-
dc.creatorEsteban, J.M. (J. M.)-
dc.creatorPardo-Balteiro, A. (A.)-
dc.creatorVelasco-Guardado, A. (A.)-
dc.creatorVázquez-Sequeiros, E. (E.)-
dc.creatorLoras, C. (C.)-
dc.creatorMartinez-Moreno, B. (B.)-
dc.creatorCastellot, A. (A.)-
dc.creatorHuertas, C. (C.)-
dc.creatorMartínez-Lapiedra, M. (M.)-
dc.creatorSánchez-Yague, A. (A.)-
dc.creatorTerán, A. (A.)-
dc.creatorMorales-Alvarado, V.J. (V. J.)-
dc.creatorBetes, M.T. (María Teresa)-
dc.creatorIglesia, D. (D.) de la-
dc.creatorSánchez-Montes, C. (C.)-
dc.creatorLozano, M.D. (María Dolores)-
dc.creatorLariño-Noia, J. (J.)-
dc.creatorGines, A. (A.)-
dc.creatorTebe, C. (C.)-
dc.creatorGornals, J.B. (J. B.)-
dc.creatorSpanish Group for EUS-Guided TA in the adrenal gland-
dc.date.accessioned2021-11-09T11:30:39Z-
dc.date.available2021-11-09T11:30:39Z-
dc.date.issued2019-
dc.identifier.citationMartín-Cardona, A. (A.); Fernández-Esparrach, G. (G.); Subtil, J.C. (José Carlos); et al. "EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study". PLOS ONE. 14 (6), 2019, e0216658es
dc.identifier.issn1932-6203-
dc.identifier.otherPMID: 31170163-
dc.identifier.urihttps://hdl.handle.net/10171/62394-
dc.description.abstractBackground: There are limited data about the role of endoscopic ultrasound-guided tissue acquisition (EUS-TA), by fine needle aspiration (EUS-FNA) or biopsy (EUS-FNB), in the evaluation of the adrenal glands (AG). The primary aim was to assess the diagnostic yield and safety. The secondary aims were the malignancy predictors, and to create a predictive model of malignancy. Methods: This was a retrospective nationwide study involving all Spanish hospitals experienced in EUS-TA of AGs. Inclusion period was from April-2003 to April-2016. Inclusion criteria: all consecutive cases that underwent EUS-TA of AGs. EUS and cytopathology findings were evaluated. Statistical analyses: diagnostic accuracy of echoendoscopist's suspicion using cytology by EUS-TA, as gold standard; multivariate logistic regression model to predict tumor malignancy. Results: A total of 204 EUS-TA of AGs were evaluated. Primary tumor locations were lung70%, others19%, and unknown11%. AG samples were adequate for cytological diagnosis in 91%, and confirmed malignancy in 60%. Diagnostic accuracy of the endosonographer's suspicion was 68%. The most common technique was: a 22-G (65%) and cytological needle (75%) with suction-syringe (66%). No serious adverse events were described. The variables most associated with malignancy were size>30mm (OR2.27; 95%CI, 1.16-4.05), heterogeneous echo-pattern (OR2.11; 95%CI, 1.1-3.9), variegated AG shape (OR2.46; 95%CI, 1-6.24), and endosonographer suspicion (OR17.46; 95%CI, 6.2-58.5). The best variables for a predictive multivariate logistic model of malignancy were age, sex, echo-pattern, and AG-shape. Conclusions: EUS-TA of the AGs is a safe, minimally invasive procedure, allowing an excellent diagnostic yield. These results suggest the possibility of developing a pre-EUS procedure predictive malignancy model.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLoS)es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectMaterias Investigacion::Ciencias de la Salud::Diagnósticoes_ES
dc.titleEUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es_ES
dc.identifier.doi10.1371/journal.pone.0216658-
dadun.citation.number6es_ES
dadun.citation.publicationNamePLOS ONEes_ES
dadun.citation.startingPagee0216658es_ES
dadun.citation.volume14es_ES

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