Full metadata record
DC Field | Value | Language |
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dc.creator | Garcia-Moure, M. (Marc) | - |
dc.creator | Martinez-Velez, N. (Naiara) | - |
dc.creator | Gonzalez-Huarriz, M. (Marisol) | - |
dc.creator | Marrodán, L. (Lucía) | - |
dc.creator | Cascallo, M. (Manel) | - |
dc.creator | Alemany-Güell, R. (Ramón) | - |
dc.creator | Patiño-García, A. (Ana) | - |
dc.creator | Alonso-Roldán, M.M. (Marta María) | - |
dc.date.accessioned | 2021-11-09T11:55:06Z | - |
dc.date.available | 2021-11-09T11:55:06Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Garcia-Moure, M. (Marc); Martinez-Velez, N. (Naiara); Gonzalez-Huarriz, M. (Marisol); et al. "The oncolytic adenovirus VCN01 promotes anti tumor effect in primitive neuroectodermal tumor models". Scientific Reports. 9 (14368), 2019, 1 - 10 | es |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.other | PMID: 31591461 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62411 | - |
dc.description.abstract | Last advances in the treatment of pediatric tumors has led to an increase of survival rates of children affected by primitive neuroectodermal tumors, however, still a significant amount of the patients do not overcome the disease. In addition, the survivors might suffer from severe side effects caused by the current standard treatments. Oncolytic virotherapy has emerged in the last years as a promising alternative for the treatment of solid tumors. In this work, we study the anti-tumor effect mediated by the oncolytic adenovirus VCN-01 in CNS-PNET models. VCN-01 is able to infect and replicate in PNET cell cultures, leading to a cytotoxicity and immunogenic cell death. In vivo, VCN-01 increased significantly the median survival of mice and led to long-term survivors in two orthotopic models of PNETs. In summary, these results underscore the therapeutic effect of VCN-01 for rare pediatric cancers such as PNETs, and warrants further exploration on the use of this virus to treat them. | es_ES |
dc.description.sponsorship | Tis work was supported by the European Union (Marie Curie IRG270459; to M.M. Alonso), the Instituto de Salud Carlos III y los Fondos Feder Europeos (PI16/0066 to M.M. Alonso), the Spanish Ministry of Science and Innovation (Ramón y Cajal contract RYC-2009–05571 and IEDI-2015-00638 to M.M. Alonso), Foundation LA CAIXA/Caja Navarra (A-PG, MMA), Foundation “El sueño de Vicky”, Association Pablo Ugarte-Fuerza Julen (A-PG, MMA), Foundation ACS (A-PG, MMA), and DOD team science award (MMA, JF, and CG-M). Tis project has received funding from the European Research Council (ERC) under the European Union´s Horizon 2020 research and innovation programme (grant agreement No. 817884; ViroPedTer). R. Alemany is supported by BIO2011–30299-C02–01 from the Spanish Ministry of Education and Science. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Science and Business Media LLC | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/817884/EU | - |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Oncología | es_ES |
dc.title | The oncolytic adenovirus VCN01 promotes anti tumor effect in primitive neuroectodermal tumor models | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | es_ES |
dc.identifier.doi | 10.1038/s41598-019-51014-1 | - |
dadun.citation.endingPage | 10 | es_ES |
dadun.citation.number | 14368 | es_ES |
dadun.citation.publicationName | Scientific Reports | es_ES |
dadun.citation.startingPage | 1 | es_ES |
dadun.citation.volume | 9 | es_ES |
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