Omics approaches in pancreatic adenocarcinoma
Keywords: 
Pancreatic adenocarcinoma
ctDNA
Proteomic
Genomic
Metabolomic
Lipidomic
FFPE
Tissue
Body fluids
Issue Date: 
2019
Publisher: 
MDPI AG
ISSN: 
2072-6694
Note: 
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Citation: 
Gonzalez, I. (Iranzu); Viudez, A. (A.); Goñi, S. (Saioa); et al. "Omics approaches in pancreatic adenocarcinoma". Cancers. 11 (8), 2019, 1052
Abstract
Pancreatic ductal adenocarcinoma, which represents 80% of pancreatic cancers, is mainly diagnosed when treatment with curative intent is not possible. Consequently, the overall five-year survival rate is extremely dismal—around 5% to 7%. In addition, pancreatic cancer is expected to become the second leading cause of cancer-related death by 2030. Therefore, advances in screening, prevention and treatment are urgently needed. Fortunately, a wide range of approaches could help shed light in this area. Beyond the use of cytological or histological samples focusing in diagnosis, a plethora of new approaches are currently being used for a deeper characterization of pancreatic ductal adenocarcinoma, including genetic, epigenetic, and/or proteo-transcriptomic techniques. Accordingly, the development of new analytical technologies using body fluids (blood, bile, urine, etc.) to analyze tumor derived molecules has become a priority in pancreatic ductal adenocarcinoma due to the hard accessibility to tumor samples. These types of technologies will lead us to improve the outcome of pancreatic ductal adenocarcinoma patients.

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