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dc.creatorLandecho, M.F. (Manuel F.)-
dc.creatorTuero, C. (Carlota)-
dc.creatorValenti, V. (Víctor)-
dc.creatorBilbao, I. (Idoia)-
dc.creatorHiguera, M. (Magdalena) de la-
dc.creatorFrühbeck, G. (Gema)-
dc.date.accessioned2021-11-11T09:37:21Z-
dc.date.available2021-11-11T09:37:21Z-
dc.date.issued2019-
dc.identifier.citationLandecho, M.F. (Manuel F.); Tuero, C. (Carlota); Valenti, V. (Víctor); et al. "Relevance of leptin and other adipokines in obesity-associated cardiovascular risk". Nutrients. 11 (11), 2019, 2664es_ES
dc.identifier.issn2072-6643-
dc.identifier.urihttps://hdl.handle.net/10171/62537-
dc.description.abstractObesity, which is a worldwide epidemic, confers increased risk for multiple serious conditions including type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular diseases. Adipose tissue is considered one of the largest endocrine organs in the body as well as an active tissue for cellular reactions and metabolic homeostasis rather than an inert tissue only for energy storage. The functional pleiotropism of adipose tissue relies on its ability to synthesize and release a large number of hormones, cytokines, extracellular matrix proteins, and growth and vasoactive factors, which are collectively called adipokines known to influence a variety of physiological and pathophysiological processes. In the obese state, excessive visceral fat accumulation causes adipose tissue dysfunctionality that strongly contributes to the onset of obesity-related comorbidities. The mechanisms underlying adipose tissue dysfunction include adipocyte hypertrophy and hyperplasia, increased inflammation, impaired extracellular matrix remodeling, and fibrosis together with an altered secretion of adipokines. This review describes the relevance of specific adipokines in the obesity-associated cardiovascular disease.es_ES
dc.description.sponsorshipGF reports grants from the Spanish Health Institute ISCIII, Subdirección General de Evaluación and Fondos FEDER PI16/01217, Plan Estatal I+D+I/2013–2016 and CIBEROBN, during the writing of this document.es_ES
dc.language.isoenges_ES
dc.publisherMDPI AGes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectObesityes_ES
dc.subjectAdipokineses_ES
dc.subjectLeptines_ES
dc.subjectResistines_ES
dc.subjectVisfatines_ES
dc.subjectOsteopontines_ES
dc.subjectAdiponectines_ES
dc.subjectOmentin-1es_ES
dc.subjectGhrelines_ES
dc.subjectObestatines_ES
dc.titleRelevance of leptin and other adipokines in obesity-associated cardiovascular riskes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.identifier.doi10.3390/nu11112664-
dadun.citation.number11es_ES
dadun.citation.publicationNameNutrientses_ES
dadun.citation.startingPage2664es_ES
dadun.citation.volume11es_ES

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