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dc.creatorEsteva‑Socias, M. (Margalida)-
dc.creatorArtiga, M.J. (María Jesús)-
dc.creatorBahamonde, O. (Olga)-
dc.creatorBelar, O. (Oihana)-
dc.creatorBermudo, R. (Raquel)-
dc.creatorCastro, E. (Erika)-
dc.creatorEscámez, T. (Teresa)-
dc.creatorFraga, M. (Máximo)-
dc.creatorJauregui‑Mosquera, L. (Laura)-
dc.creatorNovoa, I. (Isabel)-
dc.creatorPeiró‑Chova, L. (Lorena)-
dc.creatorRejón, J.D. (Juan David)-
dc.creatorRuiz‑Miró, M. (María)-
dc.creatorVieiro-Balo, P. (Paula)-
dc.creatorVillar-Campo, V. (Virginia)-
dc.creatorZazo, S. (Sandra)-
dc.creatorRábano, A. (Alberto)-
dc.creatorVillena, C. (Cristina)-
dc.date.accessioned2021-11-11T09:40:21Z-
dc.date.available2021-11-11T09:40:21Z-
dc.date.issued2019-
dc.identifier.citationEsteva‑Socias, M. (Margalida); Artiga, M.J. (María Jesús); Bahamonde, O. (Olga); et al. "In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue biospecimen research working group of the spanish biobank network". Journal of Translational Medicine. 17 (370), 2019, 370es_ES
dc.identifier.issn1479-5876-
dc.identifier.urihttps://hdl.handle.net/10171/62538-
dc.description.abstractThe purpose of the present work is to underline the importance of obtaining a standardized procedure to ensure and evaluate both clinical and research usability of human tissue samples. The study, which was carried out by the Biospecimen Science Working Group of the Spanish Biobank Network, is based on a general overview of the cur‑ rent situation about quality assurance in human tissue biospecimens. It was conducted an exhaustive review of the analytical techniques used to evaluate the quality of human tissue samples over the past 30 years, as well as their reference values if they were published, and classifed them according to the biomolecules evaluated: (i) DNA, (ii) RNA, and (iii) soluble or/and fxed proteins for immunochemistry. More than 130 publications released between 1989 and 2019 were analysed, most of them reporting results focused on the analysis of tumour and biopsy samples. A qual‑ ity assessment proposal with an algorithm has been developed for both frozen tissue samples and formalin-fxed parafn-embedded (FFPE) samples, according to the expected quality of sample based on the available pre-analytical information and the experience of the participants in the Working Group. The high heterogeneity of human tissue samples and the wide number of pre-analytic factors associated to quality of samples makes it very difcult to harmo‑ nize the quality criteria. However, the proposed method to assess human tissue sample integrity and antigenicity will not only help to evaluate whether stored human tissue samples ft for the purpose of biomarker development, but will also allow to perform further studies, such as assessing the impact of diferent pre-analytical factors on very well characterized samples or evaluating the readjustment of tissue sample collection, processing and storing procedurees_ES
dc.description.sponsorshipThis work was funded by the Ministerio de Ciencia, Innovación y Univer‑ sidades of Spain and Instituto de Salud Carlos III (PI16/00528, PI16/00946, PI16/01207 and PI16/01276), co-funded by the Spanish Biobank Network (PT13/0010/0030, PT17/0015/0001, PT17/0015/0021, PT17/0015/0049, PT17/0015/0018, PT17/0015/0002, PT17/0015/0016, PT17/0015/0038, PT17/0015/0027, PT17/0015/0004, PT17/0015/0047, PT17/0015/0014, PT17/0015/0041, and PT17/0015/0006), European Regional Development Fund (FEDER) “A way to make Europe” and granted by Conselleria d’Innovació, Recerca i Turisme del Govern de les Illes Balears (TEC/002/2017).es_ES
dc.language.isoenges_ES
dc.publisherSpringer Science and Business Media LLCes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectQualityes_ES
dc.subjectPre-analytical variableses_ES
dc.subjectBiobankes_ES
dc.subjectTissuees_ES
dc.subjectBiospecimen sciencees_ES
dc.titleIn search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue biospecimen research working group of the spanish biobank networkes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver applies to the data made available in this article, unless otherwise stated.es_ES
dc.identifier.doi10.1186/s12967-019-2124-8-
dadun.citation.number370es_ES
dadun.citation.publicationNameJournal of Translational Medicinees_ES
dadun.citation.startingPage370es_ES
dadun.citation.volume17es_ES

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