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dc.creatorBorrero-Palacios, A. (A.)-
dc.creatorCebrián, A. (A.)-
dc.creatorGarcía-Carbonero, R. (R.)-
dc.creatorGarcia-Alfonso, P. (P.)-
dc.creatorAranda, E. (E.)-
dc.creatorElez, E. (E.)-
dc.creatorLópez-López, R. (Rafael)-
dc.creatorCervantes, A. (Andrés)-
dc.creatorValladares, M. (M.)-
dc.creatorNadal, C. (C.)-
dc.creatorVieitez, J.M. (J. M.)-
dc.creatorGuillén-Ponce, C. (C.)-
dc.creatorRodríguez, J. (J.)-
dc.creatorHernandez, I. (I.)-
dc.creatorGarcía, J.L. (J. L.)-
dc.creatorVega-Bravo, R. (R.)-
dc.creatorPuime-Otin, A. (A.)-
dc.creatorMartinez-Useros, J. (Javier)-
dc.creatorPuerto-Nevado, L. (L.) del-
dc.creatorRincón, R. (R.)-
dc.creatorRodríguez-Remírez, M. (M.)-
dc.creatorRojo-Todo, F. (Federico)-
dc.creatorGarcia-Foncillas, J. (Jesús)-
dc.date.accessioned2021-11-25T11:45:03Z-
dc.date.available2021-11-25T11:45:03Z-
dc.date.issued2019-
dc.identifier.citationBorrero-Palacios, A. (A.); Cebrián, A. (A.); García-Carbonero, R. (R.); et al. "Combination of KIR2DS4 and FcγRIIa polymorphisms predicts the response to cetuximab in KRAS mutant metastatic colorectal cancer". Scientific Reports. 9 (1), 2019, 2589es
dc.identifier.issn2045-2322-
dc.identifier.urihttps://hdl.handle.net/10171/62611-
dc.description.abstractCetuximab is a standard-of-care treatment for RAS wild-type metastatic colorectal cancer (mCRC) but not for those harbor a KRAS mutation since MAPK pathway is constitutively activated. Nevertheless, cetuximab also exerts its effect by its immunomodulatory activity despite the presence of RAS mutation. The aim of this study was to determine the impact of polymorphism FcγRIIIa V158F and killer immunoglobulin-like receptor (KIR) genes on the outcome of mCRC patients with KRAS mutations treated with cetuximab. This multicenter Phase II clinical trial included 70 mCRC patients with KRAS mutated. We found KIR2DS4 gene was significantly associated with OS (HR 2.27; 95% CI, 1.08-4.77; P = 0.03). In non-functional receptor homozygotes the median OS was 2.6 months longer than in carriers of one copy of full receptor. Multivariate analysis confirmed KIR2DS4 as a favorable prognostic marker for OS (HR 6.71) in mCRC patients with KRAS mutation treated with cetuximab. These data support the potential therapeutic of cetuximab in KRAS mutated mCRC carrying non-functional receptor KIR2DS4 since these patients significantly prolong their OS even after heavily treatment. KIR2DS4 typing could be used as predictive marker for identifying RAS mutated patients that could benefit from combination approaches of anti-EGFR monoclonal antibodies and other immunotherapies to overcome the resistance mediated by mutation in RAS.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectMaterias Investigacion::Ciencias de la Saludes_ES
dc.subjectColorrectal canceres_ES
dc.titleCombination of KIR2DS4 and FcγRIIa polymorphisms predicts the response to cetuximab in KRAS mutant metastatic colorectal canceres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is licensed under a Creative Commons Attribution 4.0 International License. The original version of this article contained an error in the spelling of the author P. Garcia-Alfonso, which was incorrectly given as P. Garcia.es_ES
dc.identifier.doi10.1038/s41598-019-39291-2-
dadun.citation.number1es_ES
dadun.citation.publicationNameScientific Reportses_ES
dadun.citation.startingPage2589es_ES
dadun.citation.volume9es_ES

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