Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Albors-Vaquer, A. (A.) | - |
dc.creator | Rizvi, A. (A.) | - |
dc.creator | Matzapetakis, M. (M.) | - |
dc.creator | Lamosa, P. (P.) | - |
dc.creator | Coelho, A.V. (A. V.) | - |
dc.creator | Patel, A.B. (A. B.) | - |
dc.creator | Mande, S.C. (S. C.) | - |
dc.creator | Gaddam, S. (S.) | - |
dc.creator | Pineda-Lucena, A. (Antonio) | - |
dc.creator | Banerjee, S. (S.) | - |
dc.creator | Puchades-Carrasco, L. (Leonor) | - |
dc.date.accessioned | 2022-01-18T09:10:18Z | - |
dc.date.available | 2022-01-18T09:10:18Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Albors-Vaquer, A.; Rizvi, A.; Matzapetakis, M.; et al. "Active and prospective latent tuberculosis are associated with different metabolomic profiles: clinical potential for the identification of rapid and non-invasive biomarkers". Emerging Microbes & Infections. 9 (1), 2020, 1131-1139 | es |
dc.identifier.issn | 2222-1751 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62738 | - |
dc.description.abstract | Although 23% of world population is infected with Mycobacterium tuberculosis (M. tb), only 5-10% manifest the disease. Individuals surely exposed to M. tb that remain asymptomatic are considered potential latent TB (LTB) cases. Such asymptomatic M. tb.-exposed individuals represent a reservoir for active TB cases. Although accurate discrimination and early treatment of patients with active TB and asymptomatic M. tb.-exposed individuals are necessary to control TB, identifying those individuals at risk of developing active TB still remains a tremendous clinical challenge. This study aimed to characterize the differences in the serum metabolic profile specifically associated to active TB infected individuals or to asymptomatic M. tb.-exposed population. Interestingly, significant changes in a specific set of metabolites were shared when comparing either asymptomatic house-hold contacts of active TB patients (HHC-TB) or active TB patients (A-TB) to clinically healthy controls (HC). Furthermore, this analysis revealed statistically significant lower serum levels of aminoacids such as alanine, lysine, glutamate and glutamine, and citrate and choline in patients with A-TB, when compared to HHC-TB. The predictive ability of these metabolic changes was also evaluated. Although further validation in independent cohorts and comparison with other pulmonary infectious diseases will be necessary to assess the clinical potential, this analysis enabled the discrimination between HHC-TB and A-TB patients with an AUC value of 0.904 (confidence interval 0.81-1.00, p-value < 0.0001). Overall, the strategy described in this work could provide a sensitive, specific, and minimally invasive method that could eventually be translated into a clinical tool for TB control. | - |
dc.description.sponsorship | This study was partially supported by the New INDIGO Partnership Program on Biotechnology applied to Human Health, ERA-NET Project: INDIGO-DBT2-062 (BT/IN/ New Indigo/05/SB/2013) and BT/PR25395/NER/95/1177/ 2017 to SB. Part of the equipment used in this work was co-funded by the Generalitat Valenciana and European Regional Development Fund (FEDER) funds (PO FEDER of Comunitat Valenciana 2014-2020). | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Biomarker | - |
dc.subject | Latent tuberculosis | - |
dc.subject | Metabolomics | - |
dc.subject | NMR | - |
dc.subject | Tuberculosis | - |
dc.title | Active and prospective latent tuberculosis are associated with different metabolomic profiles: clinical potential for the identification of rapid and non-invasive biomarkers | - |
dc.type | info:eu-repo/semantics/article | - |
dc.description.note | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.identifier.doi | 10.1080/22221751.2020.1760734 | - |
dadun.citation.number | 1 | - |
dadun.citation.publicationName | Emerging Microbes & Infections | - |
dadun.citation.volume | 9 | - |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.