Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC)

Chincarini, A. (A.); Peira, E. (E.); Morbelli, S. (S.); Pardini, M. (M.); Bauckneht, M. (M.); Arbizu, J. (Javier); Castelo-Branco, M. (M.); Büsing, K.A. (K. A.); Mendonça, A. (A.) de; Didic, M. (M.); Dottorini, M. (M.); Engelborghs, S. (S.); Ferrarese, C. (C.); Frisoni, G.B. (G. B.); Garibotto, V. (V.); Guedj, E. (E.); Hausner, L. (L.); Hugon, J. (J.); Verhaeghe, J. (J.); Mecocci, P. (P.); Musarra, M. (M.); Queneau, M. (M.); Riverol, M. (Mario); Santana, I. (I.); Guerra, U.P. (U. P.); Nobili, F. (F.)

Keywords:

Amyloid PET
Visual assessment
Semi-quantification

Issue Date:

2019

Publisher:

Elsevier BV

OpenAIRE:

320030_169876 - - The Biological Basis of Cognitive Impairment due to Suspected Non-Alzheimer’s Pathology (SNAP) : Studying the interplay between amyloidosis and tau-related neurodegeneration

ISSN:

2213-1582

Note:

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).

Citation:

Chincarini, A. (A.); Peira, E. (E.); Morbelli, S. (S.); et al. "Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC)". NeuroImage: Clinical. 23 (2019), 2019, 101846

Abstract

Background amyloid-PET reading has been classically implemented as a binary assessment, although the clinical experience has shown that the number of borderline cases is non negligible not only in epidemiological studies of asymptomatic subjects but also in naturalistic groups of symptomatic patients attending memory clinics. In this work we develop a model to compare and integrate visual reading with two independent semi-quantification methods in order to obtain a tracer-independent multi-parametric evaluation. Methods We retrospectively enrolled three cohorts of cognitively impaired patients submitted to 18F-florbetaben (53 subjects), 18F-flutemetamol (62 subjects), 18F-florbetapir (60 subjects) PET/CT respectively, in 6 European centres belonging to the EADC. The 175 scans were visually classified as positive/negative following approved criteria and further classified with a 5-step grading as negative, mild negative, borderline, mild positive, positive by 5 independent readers, blind to clinical data. Scan quality was also visually assessed and recorded. Semi-quantification was based on two quantifiers: the standardized uptake value (SUVr) and the ELBA method. We used a sigmoid model to relate the grading with the quantifiers. We measured the readers accord and inconsistencies in the visual assessment as well as the relationship between discrepancies on the grading and semi-quantifications. Conclusion It is possible to construct a map between different tracers and different quantification methods without resorting to ad-hoc acquired cases. We used a 5-level visual scale which, together with a mathematical model, delivered cut-offs and transition regions on tracers that are (largely) independent from the population. All fluorinated tracers appeared to have the same contrast and discrimination ability with respect to the negative-to-positive grading. We validated the integration of both visual reading and different quantifiers in a more robust framework thus bridging the gap between a binary and a user-independent continuous scale.

URI:

https://hdl.handle.net/10171/62739

DOI:

10.1016/j.nicl.2019.101846

Appears in Collections:

DA - CUN - Medicina nuclear - Artículos de revista
DA - CUN - Neurología - Artículos de revista

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