Full metadata record
DC Field | Value | Language |
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dc.creator | Huarte, J. (Judit) | - |
dc.creator | Espuelas, S. (Socorro) | - |
dc.creator | Martinez-Oharriz, C. (Cristina) | - |
dc.creator | Irache, J.M. (Juan Manuel) | - |
dc.date.accessioned | 2022-02-09T11:25:23Z | - |
dc.date.available | 2022-02-09T11:25:23Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Huarte-Ciganda, J. (Judit); Espuelas-Millán, M. (María Socorro); Martínez-Oharriz, M. (María Cristina); et al. "Nanoparticles from Gantrez-based conjugates for the oral delivery of camptothecin". International Journal of Pharmaceutics. X. 3, 2021, 100104 | es |
dc.identifier.issn | 2590-1567 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62899 | - |
dc.description.abstract | Camptothecin (CPT) exhibits a number of challenges for its oral administration, including a low aqueous solu-bility, a lactone ring susceptible to hydrolysis, and an affinity to the intestinal P-gp. The aim of this work was to evaluate nanoparticles from Gantrez-based conjugates as carriers for the oral delivery of CPT. For this purpose two different conjugates (G-mPEG and G-HPCD), obtained by the covalent binding of either HP-beta-CD or methoxy-PEG (m-PEG) to the polymer backbone of GantrezTM AN, were synthetized and characterized. Both excipients (m -PEG and HPCD) were selected due to their reported abilities to stabilize the lactone ring of CPT and disturb the effect of intestinal P-gp. The resulting nanoparticles (G-mPEG-NP and G-HPCD-NP) presented a similar size (about 200 nm) and zeta potential (close to-35 mV); although, G-mPEG-NP presented a higher CPT payload than G-HPCD-NP. On the contrary, in rats, nanoparticles based on Gantrez conjugates appeared to be capable of crossing the protective mucus layer and reach the intestinal epithelium, whereas conventional Gantrez nano-particles displayed a mucoadhesive profile. Finally, the pharmacokinetic study revealed that both formulations were able to enhance the relative oral bioavailability of CPT; although this value was found to be 2.6-times higher for G-mPEG-NP than for G-HPCD-NP. | - |
dc.description.sponsorship | Judit Huarte was also financially supported by a grant from Asociaci ́on de Amigos de la Universidad de Navarra and from the 7th Framework Programme's Project 295218 of the International Research Staff Exchange Scheme (IRSES), Marie Curie Actions. | - |
dc.language.iso | en | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/295218/EU | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Área de Biomedicina | - |
dc.subject | Camptothecin; Nanoparticles; Oral delivery; Conjugates; Cyclodextrin; Poly(ethylene glycol) | - |
dc.title | Nanoparticles from Gantrez-based conjugates for the oral delivery of camptothecin | - |
dc.type | info:eu-repo/semantics/article | - |
dc.identifier.doi | 10.1016/j.ijpx.2021.100104 | - |
dadun.citation.publicationName | International Journal of Pharmaceutics | - |
dadun.citation.startingPage | 100104 | - |
dadun.citation.volume | 3 | - |
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