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dc.creatorAydillo-Miguel, C. (Carlos)-
dc.creatorMazo, N. (Nuria)-
dc.creatorNavo, C.D. (Claudio D.)-
dc.creatorJiménez-Osés, G. (Gonzalo)-
dc.date.accessioned2022-02-23T08:14:52Z-
dc.date.available2022-02-23T08:14:52Z-
dc.date.issued2019-
dc.identifier.citationAydillo-Miguel, C. (Carlos); Mazo, N. (Nuria); Navo, C.D. (Claudio D.); et al. "Elusive dehydroalanine derivatives with enhanced reactivity". ChemBioChem. 20 (10), 2019, 1246 - 1250es
dc.identifier.issn1439-4227-
dc.identifier.urihttps://hdl.handle.net/10171/62952-
dc.description.abstractFor the first time, a simple methodology for the chemical synthesis and use of highly reactive 4-methylenoxazol-5(4H)-ones from serine is presented. These dehydroalanine derivatives, which resemble the natural 4-methylidenimidazole-5-one (MIO) cofactor present in lyases and aminomutases, undergo rapid reaction with carbon nucleophiles such as silyl enol ethers, as well as cycloaddition reactions with diazo compounds and reactive dienes, under very mild conditions and without any need for metal catalysts or ring-strain activation, offering potential for bioconjugation.es_ES
dc.description.sponsorshipMINECO (projects CTQ2015-70524-R and RYC-2013-14706 to G.J.O. and C.D.N.) and Universidad de La Rioja (fellowship to N.M.).es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCycloadditiones_ES
dc.subjectDehydroalaninees_ES
dc.subjectDiazo compoundses_ES
dc.subjectMethylenoxazoloneses_ES
dc.subjectMethylidenimidazoleoneses_ES
dc.titleElusive dehydroalanine derivatives with enhanced reactivityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is protected by copyright. All rights reservedes_ES
dc.identifier.doi10.1002/cbic.201800758-
dadun.citation.endingPage1250es_ES
dadun.citation.number10es_ES
dadun.citation.publicationNameChemBioChemes_ES
dadun.citation.startingPage1246es_ES
dadun.citation.volume20es_ES

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