Full metadata record
DC Field | Value | Language |
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dc.creator | Jiménez-Andrés, M. (Maddalen) | - |
dc.creator | Raquel | - |
dc.creator | Elizalde, M. (María) | - |
dc.creator | Azkona, M.T. (María Teresa) | - |
dc.creator | Latasa, M.U. (María Ujué) | - |
dc.creator | Uriarte, I. (Iker) | - |
dc.creator | Arechederra, M. (María) | - |
dc.creator | Alignani, D. (Diego) | - |
dc.creator | Bárcena-Varela, M. (Marina) | - |
dc.creator | Álvarez-Sola, G. (Gloria) | - |
dc.creator | Colyn, L. (Leticia) | - |
dc.creator | Santamaría, E. (Eva) | - |
dc.creator | Sangro, B. (Bruno) | - |
dc.creator | Rodriguez-Ortigosa, C.M. (Carlos M.) | - |
dc.creator | García-Fernández-de-Barrena, M. (Maite) | - |
dc.creator | Avila, M.A. (Matías Antonio) | - |
dc.creator | Berasain, C. (Carmen) | - |
dc.date.accessioned | 2022-02-23T08:20:37Z | - |
dc.date.available | 2022-02-23T08:20:37Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Jiménez-Andrés, M. (Maddalen); Urtasun, R. (Raquel); Elizalde, M. (María); et al. "Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins". Nucleic Acids Research. 47 (7), 2019, 3450 - 3466 | es_ES |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62953 | - |
dc.description.abstract | Genome instability is related to disease development and carcinogenesis. DNA lesions are caused by genotoxic compounds but also by the dysregulation of fundamental processes like transcription, DNA replication and mitosis. Recent evidence indicates that impaired expression of RNA-binding proteins results in mitotic aberrations and the formation of transcription-associated RNA–DNA hybrids (R-loops), events strongly associated with DNA injury. We identify the splicing regulator SLU7 as a key mediator of genome stability. SLU7 knockdown results in R-loops formation, DNA damage, cell-cycle arrest and severe mitotic derangements with loss of sister chromatid cohesion (SCC). We define a molecular pathway through which SLU7 keeps in check the generation of truncated forms of the splicing factor SRSF3 (SRp20) (SRSF3-TR). Behaving as dominant negative, or by gain-of-function, SRSF3-TR impair the correct splicing and expression of the splicing regulator SRSF1 (ASF/SF2) and the crucial SCC protein sororin. This unique function of SLU7 was found in cancer cells of different tissue origin and also in the normal mouse liver, demonstrating a conserved and fundamental role of SLU7 in the preservation of genome integrity. Therefore, the dowregulation of SLU7 and the alterations of this pathway that we observe in the cirrhotic liver could be involved in the process of hepatocarcinogenesis. | es_ES |
dc.description.sponsorship | CIBERehd; Instituto de Salud Carlos III (ISCIII) [PI13/00359, PI13/00385]; MINECO/AEI/FEDER,UE [SAF2016-75972-R]; HEPACARE Project from Fundacion La Caixa; Ministerio de Educaci ´ on FPI Fellowship, ´ Cultura y Deporte; ADA-UNAV and CIMA Fellowships; AECC Post-doctoral Fellowship; Fundacion Eugenio ´ Rodr´ıguez Pascual; Fundacion Echebano; Fundaci ´ on´ Mario Losantos; Fundacion M Torres and Mrs Eduardo ´ Avila and Sergio Dur ´ a contribution. Funding for open ´ access charge: MINECO/AEI/FEDER,UE [SAF2016- 75972-R]. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press (OUP) | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Carcinogenesis | es_ES |
dc.subject | DNA lesions | es_ES |
dc.subject | Genotoxic compounds | es_ES |
dc.subject | Mitosis | es_ES |
dc.title | Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. | es_ES |
dc.identifier.doi | 10.1093/nar/gkz014 | - |
dadun.citation.endingPage | 3466 | es_ES |
dadun.citation.number | 7 | es_ES |
dadun.citation.publicationName | Nucleic Acids Research | es_ES |
dadun.citation.startingPage | 3450 | es_ES |
dadun.citation.volume | 47 | es_ES |
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