Antiviral, antimicrobial and antibiofilm activity of selenoesters and selenoanhydrides
Keywords: 
Selenoesters
Selenoanhydrides
Antivirals
Biofilm inhibitors
Antibacterials
Antifungals
HSV-2
Staphylococcus aureus
Salmonella Typhimurium
Candida spp
Issue Date: 
2019
Publisher: 
MDPI AG
ISSN: 
1420-3049
Note: 
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Citation: 
Spengler, G. (Gabriella); Kincses, A. (Annamária); Mosolygó, T. (Timea); et al. "Antiviral, antimicrobial and antibiofilm activity of selenoesters and selenoanhydrides". Molecules. 24 (23), 2019, 4264
Abstract
Selenoesters and the selenium isostere of phthalic anhydride are bioactive selenium compounds with a reported promising activity in cancer, both due to their cytotoxicity and capacity to reverse multidrug resistance. Herein we evaluate the antiviral, the biofilm inhibitory, the antibacterial and the antifungal activities of these compounds. The selenoanhydride and 7 out of the 10 selenoesters were especially potent antiviral agents in Vero cells infected with herpes simplex virus-2 (HSV-2). In addition, the tested selenium derivatives showed interesting antibiofilm activity against Staphylococcus aureus and Salmonella enterica serovar Typhimurium, as well as a moderate antifungal activity in resistant strains of Candida spp. They were inactive against anaerobes, which may indicate that the mechanism of action of these derivatives depends on the presence of oxygen. The capacity to inhibit the bacterial biofilm can be of particular interest in the treatment of nosocomial infections and in the coating of surfaces of prostheses. Finally, the potent antiviral activity observed converts these selenium derivatives into promising antiviral agents with potential medical applications..

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