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dc.creatorSpengler, G. (Gabriella)-
dc.creatorKincses, A. (Annamária)-
dc.creatorMosolygó, T. (Timea)-
dc.creatorMarc, M.A. (Malgorzata Anna)-
dc.creatorNové, M. (Márta)-
dc.creatorGajdács, M. (Márió)-
dc.creatorSanmartin-Grijalba, C. (Carmen)-
dc.creatorMcNeil, H.E. (Helen E.)-
dc.creatorBlair, J.M.A. (Jessica M. A.)-
dc.creatorDomínguez-Álvarez, E. (E.)-
dc.date.accessioned2022-03-02T08:36:25Z-
dc.date.available2022-03-02T08:36:25Z-
dc.date.issued2019-
dc.identifier.citationSpengler, G. (Gabriella); Kincses, A. (Annamária); Mosolygó, T. (Timea); et al. "Antiviral, antimicrobial and antibiofilm activity of selenoesters and selenoanhydrides". Molecules. 24 (23), 2019, 4264es
dc.identifier.issn1420-3049-
dc.identifier.urihttps://hdl.handle.net/10171/62967-
dc.description.abstractSelenoesters and the selenium isostere of phthalic anhydride are bioactive selenium compounds with a reported promising activity in cancer, both due to their cytotoxicity and capacity to reverse multidrug resistance. Herein we evaluate the antiviral, the biofilm inhibitory, the antibacterial and the antifungal activities of these compounds. The selenoanhydride and 7 out of the 10 selenoesters were especially potent antiviral agents in Vero cells infected with herpes simplex virus-2 (HSV-2). In addition, the tested selenium derivatives showed interesting antibiofilm activity against Staphylococcus aureus and Salmonella enterica serovar Typhimurium, as well as a moderate antifungal activity in resistant strains of Candida spp. They were inactive against anaerobes, which may indicate that the mechanism of action of these derivatives depends on the presence of oxygen. The capacity to inhibit the bacterial biofilm can be of particular interest in the treatment of nosocomial infections and in the coating of surfaces of prostheses. Finally, the potent antiviral activity observed converts these selenium derivatives into promising antiviral agents with potential medical applications..es_ES
dc.description.sponsorshipThe study was supported by the project SZTE ÁOK-KKA 2018/270-62-2 of the University of Szeged, Faculty of Medicine. Gabriella Spengler was also supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. The authors of this paper received funding from the Márton Áron Research Programme financed by the Hungarian Ministry of Foreign Affairs and Trade. AK was supported by the New National Excellence Program (ÚNKP-18-3) of the Ministry of Human Capacities of Hungary and by the Campus mundi short-study program of the Tempus Public Foundation. EDA was supported by the Spanish “Consejo Superior de Investigaciones Científicas” (201780I027) (CSIC, Spanish National Research Council). CSM wishes to express gratitude to UNED-Pamplona, Fundación Bancaria “La Caixa”, and “Fundación Caja Navarra” for financial support for the project. JMAB and HEM are supported by a BBSRC David Phillips Fellowship to JMAB (BB/M02623X/1).es_ES
dc.language.isoenges_ES
dc.publisherMDPI AGes_ES
dc.relationinfo:eu-repo/grantAgreement/UKRI/BBSRC/BB%2FM02623X%2F1 /GB/Targeting Periplasmic Adaptor Proteins to Improve Antibiotic Efficacy //-
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectSelenoesterses_ES
dc.subjectSelenoanhydrideses_ES
dc.subjectAntiviralses_ES
dc.subjectBiofilm inhibitorses_ES
dc.subjectAntibacterialses_ES
dc.subjectAntifungalses_ES
dc.subjectHSV-2es_ES
dc.subjectStaphylococcus aureuses_ES
dc.subjectSalmonella Typhimuriumes_ES
dc.subjectCandida sppes_ES
dc.titleAntiviral, antimicrobial and antibiofilm activity of selenoesters and selenoanhydrideses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.identifier.doi10.3390/molecules24234264-
dadun.citation.number23es_ES
dadun.citation.publicationNameMoleculeses_ES
dadun.citation.startingPage4264es_ES
dadun.citation.volume24es_ES

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