Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts
Keywords: 
Synaptophysins
Synaptogyrins
Vesicle proteins
Membrane
Issue Date: 
2019
Publisher: 
eLife Sciences Publications, Ltd
ISSN: 
2050-084X
Note: 
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Citation: 
Raja, M.K. (Mathan K.); Preobraschenski, J. (Julia); Olmo-Cabrera, S. (Sergio) del; et al. "Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts". eLife. 8, 2019, e40744
Abstract
Synaptophysins 1 and 2 and synaptogyrins 1 and 3 constitute a major family of synaptic vesicle membrane proteins. Unlike other widely expressed synaptic vesicle proteins such as vSNAREs and synaptotagmins, the primary function has not been resolved. Here, we report robust elevation in the probability of release of readily releasable vesicles with both high and low release probabilities at a variety of synapse types from knockout mice missing all four family members. Neither the number of readily releasable vesicles, nor the timing of recruitment to the readily releasable pool was affected. The results suggest that family members serve as negative regulators of neurotransmission, acting directly at the level of exocytosis to dampen connection strength selectively when presynaptic action potentials fire at low frequency. The widespread expression suggests that chemical synapses may play a frequency filtering role in biological computation that is more elemental than presently envisioned.

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