Full metadata record
DC Field | Value | Language |
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dc.creator | Razquin, C. (Cristina) | - |
dc.creator | Ruiz-Canela, M. (Miguel) | - |
dc.creator | Clish, C.B. (Clary B.) | - |
dc.creator | Li, J. (Jun) | - |
dc.creator | Toledo, E. (Estefanía) | - |
dc.creator | Dennis, C. (Courtney) | - |
dc.creator | Liang, L. (Liming) | - |
dc.creator | Salas-Huetos, A. (Albert) | - |
dc.creator | Pierce, K.A. (Kerry A.) | - |
dc.creator | Guasch-Ferre, M. (Marta) | - |
dc.creator | Corella, D. (Dolores) | - |
dc.creator | Ros, E. (Emilio) | - |
dc.creator | Estruch, R. (Ramón) | - |
dc.creator | Gomez-Gracia, E. (Enrique) | - |
dc.creator | Fito, M. (Montserrat) | - |
dc.creator | Lapetra, J. (José) | - |
dc.creator | Romaguera, D. (Dora) | - |
dc.creator | Alonso-Gomez, A. (Ángel) | - |
dc.creator | Serra-Majem, L. (Luis) | - |
dc.creator | Salas-Salvado, J. (Jordi) | - |
dc.creator | Hu, F.B. (Frank B.) | - |
dc.creator | Martinez-Gonzalez, M.A. (Miguel Ángel) | - |
dc.date.accessioned | 2022-03-11T13:47:32Z | - |
dc.date.available | 2022-03-11T13:47:32Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Razquin, C. (Cristina); Ruiz-Canela, M. (Miguel); Clish, C.B. (Clary B.); et al. "Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies". Cardiovascular Diabetology. 18 (151), 2019, | es |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | https://hdl.handle.net/10171/63155 | - |
dc.description.abstract | Background: The pandemic of cardiovascular disease (CVD) and type 2 diabetes (T2D) requires the identifcation of new predictor biomarkers. Biomarkers potentially modifable with lifestyle changes deserve a special interest. Our aims were to analyze: (a) The associations of lysine, 2-aminoadipic acid (2-AAA) or pipecolic acid with the risk of T2D or CVD in the PREDIMED trial; (b) the efect of the dietary intervention on 1-year changes in these metabolites, and (c) whether the Mediterranean diet (MedDiet) interventions can modify the efects of these metabolites on CVD or T2D risk. Methods: Two unstratifed case-cohort studies nested within the PREDIMED trial were used. For CVD analyses, we selected 696 non-cases and 221 incident CVD cases; for T2D, we included 610 non-cases and 243 type 2 diabetes incident cases. Metabolites were quantifed using liquid chromatography–tandem mass spectrometry, at baseline and after 1-year of intervention. Results: In weighted Cox regression models, we found that baseline lysine (HR+1 SD increase=1.26; 95% CI 1.06–1.51) and 2-AAA (HR+1 SD increase=1.28; 95% CI 1.05–1.55) were both associated with a higher risk of T2D, but not with CVD. A signifcant interaction (p=0.032) between baseline lysine and T2D on the risk of CVD was observed: subjects with prevalent T2D and high levels of lysine exhibited the highest risk of CVD. The intervention with MedDiet did not have a signifcant efect on 1-year changes of the metabolites. Conclusions: Our results provide an independent prospective replication of the association of 2-AAA with future risk of T2D. We show an association of lysine with subsequent CVD risk, which is apparently diabetes-dependent. No evidence of efects of MedDiet intervention on lysine, 2-AAA or pipecolic acid changes was found. | es_ES |
dc.description.sponsorship | This research was supported by the National Institutes of Health HL118264, R01DK102896 and 2R01HL118264; Instituto de Salud Carlos III, Madrid, Spain: RD06/0045, RTIC G03/140, and CIBERobn (CB06/03). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Science and Business Media LLC | es_ES |
dc.relation | info:eu-repo/grantAgreement/NIH/NATIONAL_INSTITUTE_OF_DIABETES_AND_DIGESTIVE_AND_KIDNEY_DISEASES/1R01DK102896-01/US | - |
dc.relation | info:eu-repo/grantAgreement/NIH/NATIONAL_HEART,_LUNG,_AND_BLOOD_INSTITUTE/4R01HL118264-04/US | - |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Biomarkers | es_ES |
dc.subject | Metabolites | es_ES |
dc.subject | Cardiovascular disease | es_ES |
dc.subject | Type 2 diabetes | es_ES |
dc.subject | Dietary intervention | es_ES |
dc.title | Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | es_ES |
dc.identifier.doi | 10.1186/s12933-019-0958-2 | - |
dadun.citation.number | 151 | es_ES |
dadun.citation.publicationName | Cardiovascular Diabetology | es_ES |
dadun.citation.volume | 18 | es_ES |
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