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dc.creatorArpon, A. (Ana)-
dc.creatorMilagro-Yoldi, F.I. (Fermín Ignacio)-
dc.creatorSantos, J.L. (José Luis)-
dc.creatorGarcia-Granero, M. (Marta)-
dc.creatorRiezu-Boj, J.I. (José Ignacio)-
dc.creatorMartinez, J.A. (José Alfredo)-
dc.identifier.citationArpon, A. (Ana); Milagro, F.I. (Fermín I.); Santos, J.L. (José Luis); et al. "Interaction among sex, aging, and epigenetic processes concerning visceral fat, insulin resistance, and dyslipidaemia". Frontiers in Endocrinology. 10, 2019, 496es
dc.description.abstractThe distribution of adipose tissue is influenced by gender and by age, shifting from subcutaneous to visceral depots with longevity, increasing the development of several aging-related diseases and manifestations such as obesity, metabolic syndrome, and insulin resistance. Epigenetics might have an important role in aging processes. The aim of this research was to investigate the interactions between aging and epigenetic processes and the role of visceral adipose tissue, insulin resistance, and dyslipidaemia. Two different study samples of 366 and 269 adult participants were analyzed. Anthropometric, biochemical (including the triglycerides-glucose (TyG) index), and blood pressure measurements were assessed following standardized methods. Body composition measurements by Dual-energy X-ray absorptiometry (DXA) were also performed for the second sample. Methylation data were assessed by Infinium Human Methylation BeadChip (Illumina) in peripheral white blood cells. Epigenetic age acceleration was calculated using the methods DNAmAge (AgeAcc) and GrimAge (AgeAccGrim). Age acceleration (AgeAccGrim) showed better correlations than AgeAcc with most of the measured variables (waist circumference, glucose, HOMA-IR, HDL-cholesterol, triglycerides, and TyG index) for the first sample. In the second sample, all the previous correlations were confirmed, except for HOMA-IR. In addition, many of the anthropometrical measurements assessed by DXA and C-reactive protein (CRP) were also statistically associated with AgeAccGrim. Associations separated by sex showed statistically significant correlations between AgeAccGrim and HDL-cholesterol or CRP in women, whereas, in men, the association was with visceral adipose tissue mass DXA, triglycerides and TyG index. Linear regression models (model 1 included visceral adipose tissue mass DXA and TyG index and model 2 included HDL-cholesterol and CRP) showed a significant association for men concerning visceral adipose tissue mass DXA and TyG index, while HDL-cholesterol and CRP were associated in women. Moreover, structural equation modeling showed that the TyG index was mediating the majority of the visceral adipose tissue mass action on age acceleration. Collectively, these findings showed that there are different mechanisms affecting epigenetic age acceleration depending on sex. The identified relationships between epigenetic age acceleration and disease markers will contribute to the understanding of the development of age-related diseases.es_ES
dc.description.sponsorshipThis work was supported by grants from the Government of Navarra (PT024), CIBERobn (CB12/03/30002) and Ministerio de Economía y Competitividad (AGL2013-45554-R). AA was supported by a Formación de Profesorado Universitario predoctoral fellowship from Ministerio de Educación, Cultura y Deporte (FPU15/02790).es_ES
dc.publisherFrontiers Media SAes_ES
dc.subjectDNA methylationes_ES
dc.subjectVisceral adipose tissuees_ES
dc.subjectC-reactive proteines_ES
dc.subjectTyG indexes_ES
dc.titleInteraction among sex, aging, and epigenetic processes concerning visceral fat, insulin resistance, and dyslipidaemiaes_ES
dc.description.noteThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.es_ES
dadun.citation.publicationNameFrontiers in Endocrinologyes_ES

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