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dc.creatorRodriguez-Nogales, C. (Carlos)-
dc.creatorSebastian, V. (Víctor)-
dc.creatorBlanco-Prieto, M.J. (María José)-
dc.creatorCouvreur, P. (Patrick)-
dc.creatorDesmaële, D. (Didier)-
dc.date.accessioned2022-04-05T08:43:10Z-
dc.date.available2022-04-05T08:43:10Z-
dc.date.issued2021-12-14-
dc.identifier.citationRodriguez-Nogales, C. (Carlos); Sebastian, V. (Víctor); Blanco-Prieto, M.J. (María José); et al. "Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumors". ChemMedChem. 16 (24), 2021-12-14, 3730 - 3738es_ES
dc.identifier.issn1860-7179-
dc.identifier.urihttps://hdl.handle.net/10171/63341-
dc.description.abstractTherapeutic perspectives of bone tumors such as osteosarcom are main restricted due to the inefficacy of current treatments. We propose here the construction of a novel anticancers qualene-based nanomedicine with bone affinity and retention capacity. A squalenyl-hydroxybisphosphonate molecule was synthetized by chemical conjugation of a 1-hydroxyl-1,1-bi-sphosphonatemoiety to the squalenechain. This amphiphilic compound was inserted onto squalenoyl-gemcitabinenano-particles using the nanoprecipitation method. The co-assemblyled to nanoconstructsof 75 nm, with different morphology and colloidal properties. The presence of squalenyl-hydroxybi-sphosphonate enhanced the nanoparticles binding affinity for hydroxyapatite,a mineral present in the bone. Moreover, the in vitro anticancer activity was preserved when tested in commercial and patient-treated derived pedia tricoste osarcomacells. Furtherin vivo studies will shed lighton the potential of these nano medicines for the treatment of bones arcomas.es_ES
dc.description.sponsorshipAsociación Española Contra el Cáncer (AECC) (CI14142069BLAN), Fundación Caja Navarra/Obra Social La Caixa and the Asociación de familiares y amigos de pacientes con neuroblastoma (NEN, Nico contra el cáncer) are gratefully acknowledged. CIBER-BBN is an initiative funded by the VI Spanish National R&D&i Plan 2008–2011, Iniciativa Ingenio 2010, Consolider Program, CIBERActions and financed by the Instituto de Salud Carlos III (Spain) with assistance from the European Regional Development Fund.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectOsteosarcomees_ES
dc.subjectAntitumor agentses_ES
dc.subjectNanoparticleses_ES
dc.subjectHydroxyapatitees_ES
dc.titleDecoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumorses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open access article under the terms of the Creative Commons Attribution Non-Commercial No Derivs Licensees_ES
dc.identifier.doi10.1002/cmdc.202100464-
dadun.citation.endingPage3738es_ES
dadun.citation.number24es_ES
dadun.citation.publicationNameChemMedChemes_ES
dadun.citation.startingPage3730es_ES
dadun.citation.volume16es_ES

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