Interleukin-12 message in a bottle
Keywords: 
Interleukin-12
Immunotherapy
Lipid-nanoparticle mRNA
Issue Date: 
2020
Publisher: 
American Association for Cancer Research
ISSN: 
1078-0432
Citation: 
Cirella, A. (Assunta); Berraondo, P. (Pedro); Di-Trani, C.A. (Carla Augusta); et al. "Interleukin-12 message in a bottle". Clinical cancer research. 26 (23), 2020, 6080 - 6082
Abstract
IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial.

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