DADUN: Interleukin-12 message in a bottle

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Interleukin-12 message in a bottle

Autor(es):

Cirella, A. (Assunta)

Berraondo, P. (Pedro)

Di-Trani, C.A. (Claudia Augusta)

Melero, I. (Ignacio)

Palabras clave :

Interleukin-12
Immunotherapy
Lipid-nanoparticle mRNA

Fecha de publicación :

2020

Editorial :

American Association for Cancer Research

Proyecto:

765394 - Tumor-Treg-Targeting - Training Network for the education of the next generation scientist in targeting the supressive capacity of regulatory T-cells specifically within tumours
635122 - PROCROP - Professional cross-priming for ovary and prostate cancer
643638 - TRANSCAN-2 - ERA-NET: Aligning national/regional translational cancer research programmes and activities

ISSN :

1078-0432

Cita:

Cirella, A. (Assunta); Berraondo, P. (Pedro); Di-Trani, C.A. (Carla Augusta); et al. "Interleukin-12 message in a bottle". Clinical cancer research. 26 (23), 2020, 6080 - 6082

Resumen

IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial.

URI :

https://hdl.handle.net/10171/63353

DOI:

10.1158/1078-0432.CCR-20-3250

Aparece en las colecciones:

DA - CIMA - Inmunología e inmunoterapia - Inmunoterapia - Artículos de Revista

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IL12 message in a bottle.pdf

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