Full metadata record
DC FieldValueLanguage
dc.creatorAranaz-Oroz, P. (Paula)-
dc.creatorNavarro-Herrera, D. (David)-
dc.creatorZabala, M. (María)-
dc.creatorMiguéliz-Basterra, I. (Itziar)-
dc.creatorRomo‐Hualde, A. (Ana)-
dc.creatorLópez-Yoldi, M. (Miguel)-
dc.creatorMartinez, J.A. (José Alfredo)-
dc.creatorVizmanos-Pérez, J.L. (José Luis)-
dc.creatorMilagro-Yoldi, F.I. (Fermín Ignacio)-
dc.creatorGonzalez-Navarro, C.J. (Carlos Javier)-
dc.date.accessioned2022-04-06T09:06:12Z-
dc.date.available2022-04-06T09:06:12Z-
dc.date.issued2019-
dc.identifier.citationAranaz-Oroz, P. (Paula); Navarro-Herrera, D. (David); Zabala, M. (María); et al. "Phenolic compounds inhibit 3T3-L1 adipogenesis depending on the stage of differentiation and their binding affinity to PPARγ". Molecules. 24 (6), 2019, 1045es_ES
dc.identifier.issn1420-3049-
dc.identifier.urihttps://hdl.handle.net/10171/63356-
dc.description.abstractPhenolic compounds might modulate adiposity. Here, we report our observation that polyphenols and phenolic acids inhibit adipogenesis in 3T3-L1 with different intensity depending on the family and the stage of differentiation. While quercetin and resveratrol inhibited lipid accumulation along the whole process of differentiation, apigenin and myricetin were active during the early and latest stages, but not intermediate, contrary to hesperidin. The activity of phenolic acids was limited to the early stages of the differentiation process, except p-coumaric and ellagic acids. This anti-adipogenic effect was accompanied by down-regulation of Scd1 and Lpl. Molecular docking analysis revealed that the inhibitory activity of these phenolic compounds over the early stages of adipogenesis exhibits a significant correlation (r = 0.7034; p = 0.005) with their binding affinity to the ligand-binding domain of PPARγ. Results show that polyphenols and phenolic acids would interact with specific residues of the receptor, which could determine their potential anti-adipogenic activity during the early stages of the differentiation. Residues Phe264, His266, Ile281, Cys285 and Met348 are the most frequently involved in these interactions, which might suggest a crucial role for these amino acids modulating the activity of the receptor. These data contribute to elucidate the possible mechanisms of phenolic compounds in the control of adipogenesis.es_ES
dc.description.sponsorshipThis work was performed in the Centre for Nutrition Research (University of Navarra) with the financial support of LABORATORIOS CINFA, S.A. and VISCOFAN S.A.es_ES
dc.language.isoenges_ES
dc.publisherMDPI AGes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectAdipogenesises_ES
dc.subjectAdipocytees_ES
dc.subject3T3-L1es_ES
dc.subjectPolyphenoles_ES
dc.subjectPhenolic acides_ES
dc.subjectPPARγes_ES
dc.subjectNile redes_ES
dc.titlePhenolic compounds inhibit 3T3-L1 adipogenesis depending on the stage of differentiation and their binding affinity to PPARγes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.identifier.doi10.3390/molecules24061045-
dadun.citation.number6es_ES
dadun.citation.publicationNameMoleculeses_ES
dadun.citation.startingPage1045es_ES
dadun.citation.volume24es_ES

Files in This Item:
Thumbnail
File
molecules-24-01045.pdf
Description
Size
6.73 MB
Format
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.