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dc.creatorMata-Fernández, A. (Arantxa)-
dc.creatorHershey-de-la-Cruz, M.S. (María Soledad)-
dc.creatorPastrana-Delgado, J. (Juan)-
dc.creatorSotos-Prieto, M. (Mercedes)-
dc.creatorRuiz-Canela, M. (Miguel)-
dc.creatorKales, S.N. (Stefanos N.)-
dc.creatorMartinez-Gonzalez, M. A. (Miguel Ángel)-
dc.creatorFernandez-Montero, A. (Alejandro)-
dc.identifier.citationMata-Fernández, A. (Arantxa); Hershey-de-la-Cruz, M.S. (María Soledad); Pastrana-Delgado, J. (Juan); et al. "A Mediterranean lifestyle reduces the risk of cardiovascular disease in the “Seguimiento Universidad de Navarra” (SUN) cohort". Nutrition, Metabolism and Cardiovascular Diseases. (36), 2021, 1728 - 1737es_ES
dc.description.abstractBackground and aims: A healthy lifestyle is essential to prevent cardiovascular disease (CVD). However, beyond dietary habits, there is a scarcity of studies comprehensively assessing the typical traditional Mediterranean lifestyle with a multi-dimensional index. We assessed the association between the Mediterranean lifestyle (measured with the MEDLIFE index including diet, physical activity, and other lifestyle factors) and the incidence of CVD. Methods and results: The “Seguimiento Universidad de Navarra” (SUN) project is a prospective, dynamic and multipurpose cohort of Spanish university graduates. We calculated a MEDLIFE score, composed of 28 items on food consumption, dietary habits, physical activity, rest, social habits, and conviviality, for 18,631 participants by assigning 1 point for each typical Mediterra- nean lifestyle factor achieved, for a theoretically possible final score ranging from 0 to 28 points. During an average follow-up of 11.5 years, 172 CVD cases (myocardial infarction, stroke or cardio- vascular death) were observed. An inverse association between the MEDLIFE score and the risk of primary cardiovascular events was observed, with multivariable-adjusted hazard ratio (HR) Z 0.50; (95% confidence interval, 0.31e0.81) for the highest MEDLIFE scores (14e23 points) compared to the lowest scores (0e9 points), p (trend) Z 0.004. Conclusion: A higher level of adherence to the Mediterranean lifestyle was significantly associ- ated with a lower risk of CVD in a Spanish cohort. Public health strategies should promote the Mediterranean lifestyle to preserve cardiovascular health.es_ES
dc.description.sponsorshipMAMG and MRC were supported by and Advanced Research Grant of the European Research Council (Agreement 340918). The SUN Project has received funding from the Spanish Government-Instituto de Salud Carlos III, the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI13/00615, PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795 and G03/140), the Navarra Regional Government (27/2011, 45/2011, 122/2014), and the University of Navarra.es_ES
dc.subjectCardiovascular riskes_ES
dc.subjectMEDLIFE indexes_ES
dc.subjectMediterranean lifestylees_ES
dc.subjectSUN cohortes_ES
dc.titleA Mediterranean lifestyle reduces the risk of cardiovascular disease in the “Seguimiento Universidad de Navarra” (SUN) cohortes_ES
dc.description.noteThis is an open access article under the CC BY-NC-ND licensees_ES
dadun.citation.publicationNameNutrition, Metabolism and Cardiovascular Diseaseses_ES

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