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dc.creatorSanchez-Bayona, R. (Rodrigo)-
dc.creatorGardeazabal, I. (Itziar)-
dc.creatorRomanos-Nanclares, A. (Andrea)-
dc.creatorFernández-Lázaro, C.I. (César I.)-
dc.creatorÁlvarez-Álvarez, I. (Ismael)-
dc.creatorRuiz-Canela, M. (Miguel)-
dc.creatorGea, A. (Alfredo)-
dc.creatorMartinez-Gonzalez, M.A. (Miguel Ángel)-
dc.creatorSantisteban, M. (Marta)-
dc.creatorToledo, E. (Estefanía)-
dc.date.accessioned2022-04-26T08:28:28Z-
dc.date.available2022-04-26T08:28:28Z-
dc.date.issued2021-
dc.identifier.citationSanchez-Bayona, R. (Rodrigo); Gardeazabal, I. (Itziar); Romanos-Nanclares, A. (Andrea); et al. "Leisure-time physical activity, sedentary behavior, and risk of breast cancer: Results from the SUN (‘Seguimiento Universidad De Navarra’) project". Preventive Medicine. (148), 2021, 106535es_ES
dc.identifier.issn0091-7435-
dc.identifier.urihttps://hdl.handle.net/10171/63422-
dc.description.abstractEvidence is still limited on the influence of sedentary lifestyles on breast cancer (BC) risk. Also, prospective information on the combined effects of both sedentariness and leisure-time physical activity (LTPA) is scarce. We aimed to assess the association of higher sedentary behavior and LTPA (separately and in combination) with the risk of BC in a middle-aged cohort of university graduates. The SUN Project is a follow-up study initiated in 1999 with recruitment permanently open. Baseline assessments included a validated questionnaire on LTPA and sedentary habits. Subsequently, participants completed biennial follow-up questionnaires. Multivariable adjusted Cox models were used to estimate the hazard ratios (HR) for incident BC according to LTPA, TV-watching, the joint classification of both, and a combined 8-item multidimensional active lifestyle score. We included 10,812 women, with 11.8 years of median follow-up of. Among 115,802 women-years of follow-up, we confirmed 101 incident cases of BC. Women in the highest category of LTPA (>16.5 MET-h/week) showed a significantly lower risk of BC (HR = 0.55; 95% CI: 0.34–0.90) compared to women in the lowest category (≤6 MET/h-week). Women watching >2 h/d of TV sh owed a higher risk (HR = 1.67; 95% CI:1.03–2.72) than those who watched TV <1 h/d. Women in the highest category (6–8 points) of the multidimensional combined 8-item score showed a lower BC risk (HR = 0.35; 95% CI: 0.15–0.79) than those in the lowest category (<2 points) group. There was no significant supra-multiplicative interaction between TV-watching and LTPA. Both low LTPA and TV-watching >2 h/d may substantially increase BC risk, independently of each other.es_ES
dc.description.sponsorshipThe SUN Project has received funding from the Spanish Government Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, and G03/140), the Navarra Regional Government (45/2011, 122/2014, 41/2016), and the University of Navarra.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectBreast canceres_ES
dc.subjectPhysical activityes_ES
dc.subjectSedentary behaviores_ES
dc.subjectCohortes_ES
dc.titleLeisure-time physical activity, sedentary behavior, and risk of breast cancer: Results from the SUN (‘Seguimiento Universidad De Navarra’) projectes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open access article under the CC BY-NC-ND licensees_ES
dc.identifier.doi10.1016/j.ypmed.2021.106535-
dadun.citation.number148es_ES
dadun.citation.publicationNamePreventive Medicinees_ES
dadun.citation.startingPage106535es_ES

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