Preparation and evaluation of PEG-coated zein nanoparticles for oral drug delivery purposes
Keywords: 
Nanoparticles
Zein
PEG
Mucus-permeating
Oral delivery
Issue Date: 
2021
Publisher: 
Elsevier
ISSN: 
0378-5173
Note: 
This is an open access article under the CC BY-NC-ND license
Citation: 
Reboredo-Fuentes, C. (Cristian); Gonzalez-Navarro, C.J. (Carlos Javier); Martinez-Oharriz, C. (Cristina); et al. "Preparation and evaluation of PEG-coated zein nanoparticles for oral drug delivery purposes". International Journal of Pharmaceutics. (597), 2021, 120287
Abstract
The aim was to produce PEG-coated nanoparticles (NP-PEG), with mucus-permeating properties, for oral drug delivery purposes by using simple procedures and regulatory-approved compounds in order to facilitate a po- tential clinical development. For this purpose, zein nanoparticles were prepared by desolvation and, then, coated by incubation with PEG 35,000. The resulting nanocarriers displayed a mean size of about 200 nm and a negative zeta potential. The presence of PEG on the surface of nanoparticles was evidenced by electron microscopy and confirmed by FTIR analysis. Likely, the hydrophobic surface of zein nanoparticles (NP) was significantly reduce by their coating with PEG. This increase of the hydrophilicity of PEG-coated nanoparticles was associated with an important increase of their mobility in pig intestinal mucus. In laboratory animals, NP-PEG (fluorescently labelled with Lumogen® Red 305) displayed a different behavior when compared with bare nanoparticles. After oral administration, NP appeared to be trapped in the mucus mesh, whereas NP-PEG were capable of crossing the protective mucus layer and reach the epithelium. Finally, PEG-coated zein nanoparticles, prepared by a simple and reproducible method without employing reactive reagents, may be adequate carriers for promoting the oral bioavailability of biomacromolecules and other biologically active compounds with low permeability properties

Files in This Item:
Thumbnail
File
1-s2.0-S0378517321000910-main.pdf
Description
Size
7.53 MB
Format
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.