Obesity as an adipose tissue dysfunction disease and a risk factor for infections – Covid-19 as a case study
Keywords: 
Obesity
SARS-CoV-2
COVID-19
Cytokine storm
Adipokines
Leptin
Adiponectin
ARDS
Mortality
Diabetes mellitus
Bariatric surgery
Hypertension
Issue Date: 
2021
Publisher: 
Elsevier
ISSN: 
0953-6205
Note: 
This is an open access article under the CC license
Citation: 
Landecho, M.F. (Manuel F.); Marín-Oto, M. (Marta); Recalde-Zamacona, B. (Borja); et al. "Obesity as an adipose tissue dysfunction disease and a risk factor for infections – Covid-19 as a case study". European Journal of Internal Medicine. (91), 2021, 3 - 9
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically relevant, the underlying mechanisms are not fully elucidated. SARS CoV2 enters host cells via the Angiotensin Converting Enzyme 2 receptor, that is also expressed in adipose tissue. Moreover, adipose tissue is also a source of many proinflammatory mediators and adipokines that might enhance the characteristic COVID-19 cytokine storm due to a chronic low-grade inflammatory preconditioning. Further obesity-dependent thoracic mechanical constraints may also incise negatively into the prognosis of obese subjects with COVID-19. This review summarizes the current body of knowledge on the obesity-dependent circumstances triggering an increased risk for COVID-19 severity, and their clinical relevance

Files in This Item:
Thumbnail
File
1-s2.0-S0953620521000972-main.pdf
Description
Size
1.16 MB
Format
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.