Associations between mental and physical conditions in children and adolescents: An umbrella review
Keywords: 
Mental
Physical
Transdiagnostic
Umbrella review
Meta-analysis
Issue Date: 
2022
ISSN: 
0149-7634
Note: 
his is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Citation: 
Arrondo-Ostiz, G. (Gonzalo); Solmi, M.; Dragioti, E.; et al. "Associations between mental and physical conditions in children and adolescents: An umbrella review". Neuroscience and Biobehavioral Reviews. 137, 2022, 104662
Abstract
We mapped the evidence on the type and strength of associations between a broad range of mental and physical conditions in children and adolescents, by carrying out an umbrella review, i.e., a quantitative synthesis of previous systematic reviews and meta-analyses. We also assessed to which extent the links between mental and physical conditions vary across disorders or, by contrast, are transdiagnostic. Based on a pre-established protocol, we retained 45 systematic reviews/meta-analyses, encompassing around 12.5 million of participants. In analyses limited to the most rigorous estimates, we found evidence for the following associations: ADHD-asthma, ADHD-obesity, and depression-asthma. A transdiagnostic association was confirmed between asthma and anxiety/ASD/depression/bipolar disorder, between obesity and ADHD/ASD/depression, and between dermatitis and ASD/ADHD. We conclude that obesity and allergic conditions are likely to be associated with mental disorders in children and adolescents. Our results can help clinicians explore potential links between mental and physical conditions in children/adolescent and provide a road map for future studies aimed at shading light on the underlying factors.

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