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dc.creatorArpon, A. (Ana)-
dc.creatorMilagro-Yoldi, F.I. (Fermín Ignacio)-
dc.creatorRamos-López, O. (Omar)-
dc.creatorMansego-Talavera, M.L. (María Luisa)-
dc.creatorRiezu-Boj, J.I. (José Ignacio)-
dc.creatorMartinez, J.A. (José Alfredo)-
dc.identifier.citationArpon, A. (Ana); Milagro, F.I. (Fermín I.); Ramos-López, O. (Omar); et al. "Methylome-wide association study in peripheral white blood cells focusing on central obesity and inflammation". V. 10 (6), 2019, 444es_ES
dc.description.abstractEpigenetic signatures such as DNA methylation may be associated with specific obesity traits in different tissues. The onset and development of some obesity-related complications are often linked to visceral fat accumulation. The aim of this study was to explore DNA methylation levels in peripheral white blood cells to identify epigenetic methylation marks associated with waist circumference (WC). DNA methylation levels were assessed using Infinium HumanMethylation 450K and MethylationEPIC beadchip (Illumina) to search for putative associations with WC values of 473 participants from the Methyl Epigenome Network Association (MENA) project. Statistical analysis and Ingenuity Pathway Analysis (IPA) were employed for assessing the relationship between methylation and WC. A total of 669 CpGs were statistically associated with WC (FDR < 0.05, slope ≥ |0.1|). From these CpGs, 375 CpGs evidenced a differential methylation pattern between females with WC ≤ 88 and > 88 cm, and 95 CpGs between males with WC ≤ 102 and > 102 cm. These differentially methylated CpGs are located in genes related to inflammation and obesity according to IPA. Receiver operating characteristic (ROC) curves of the top four significant differentially methylated CpGs separated by sex discriminated individuals with presence or absence of abdominal fat. ROC curves of all the CpGs from females and one CpG from males were validated in an independent sample (n = 161). These methylation results add further insights about the relationships between obesity, adiposity-associated comorbidities, and DNA methylation where inflammation processes may be involved.es_ES
dc.description.sponsorshipThis work was supported by grants from the Government of Navarra (PT024), CIBERobn (CB12/03/30002), and the Ministerio de Economía y Competitividad (AGL2013-45554-R). A.A was supported by a “Formación de Profesorado Universitario” predoctoral fellowship from the Ministerio de Educación, Cultura y Deporte (FPU15/02790). O.R.L. was supported by a postdoctoral grant from the National Council of Science and Technology from Mexico (CONACyT, Num. CVU. 444175) in collaboration with the Doctoral Program in Sciences in Molecular Biology in Medicine (CONACyT, PNPC 000091).es_ES
dc.publisherMDPI AGes_ES
dc.subjectWaist circumferencees_ES
dc.subjectDNA methylatioes_ES
dc.titleMethylome-wide association study in peripheral white blood cells focusing on central obesity and inflammationes_ES
dc.description.noteThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)es_ES

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