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dc.creatorMacías, M. (Mónica)-
dc.creatorGarcía-Cortés, Á. (Ángel)-
dc.creatorTorres, M. (Marcos)-
dc.creatorAncizu-Marckert, J. (Javier)-
dc.creatorPascual, J.I. (Juan Ignacio)-
dc.creatorDíez-Caballero, F. (Fernando)-
dc.creatorRobles-Garcia, J.E. (José Enrique)-
dc.creatorRosell, D. (David)-
dc.creatorMiñana-López, B. (Bernardino)-
dc.creatorMateos, B. (Beatriz)-
dc.creatorAjona, D. (Daniel)-
dc.creatorSanchez-Bayona, R. (Rodrigo)-
dc.creatorBedialauneta, O. (Oihane)-
dc.creatorChocarro, S. (Susana)-
dc.creatorNavarro, A. (Ana)-
dc.creatorAndueza, M.P. (Maria P.)-
dc.creatorGurpide, A. (Alfonso)-
dc.creatorPerez-Gracia, J.L. (Jose Luis)-
dc.creatorAlegre-Martinez, E. (Estibaliz)-
dc.creatorGonzalez-Hernandez, A. (Alvaro)-
dc.date.accessioned2022-06-28T08:11:04Z-
dc.date.available2022-06-28T08:11:04Z-
dc.date.issued2021-
dc.identifier.citationMacías, M. (Mónica); García-Cortés, Á. (Ángel); Torres, M. (Marcos); et al. "Characterization of the perioperative changes of exosomal immune-related cytokines induced by prostatectomy in early-stage prostate cancer patients". Cytokine. (141), 2021, 155471es_ES
dc.identifier.issn1043-4666-
dc.identifier.urihttps://hdl.handle.net/10171/63694-
dc.description.abstractBackground: Myeloid-derived suppressor cells (MDSCs) are relevant in prostate cancer microenvironment collaborating in tumor development. The main tumor marker used in this disease, prostate-specific antigen (PSA), does not provide information related to this tumor microenvironment. Cancer cells secrete exosomes carrying bioactive molecules contributing to MDSCs recruitment and induction. The aim of this study was to characterize the perioperative changes of exosomal cytokines relevant in MDSCs recruitment induced by pros- tatectomy in prostate cancer patients. Methods: Blood was drawn from 26 early-stage prostate cancer patients before and after radical prostatectomy and from 16 healthy volunteers. Serum exosomes were separated by precipitation. Cytokines related with MDSC cell recruitment and activation CCL2, CXCL2, CXCL5, CXCL8, CXCL12, MIF, S100A9 and TGF-ß were measured in serum and serum-derived exosomes using immunometric assays. Results: All cytokines were detected both in serum and exosomes, except for CXCL12, which was detected only in serum. Exosomes were enriched specially in MIF, TGF-ß and CXCL2. Presurgical MIF levels in exosomes correlated negatively with serum PSA. Also, presurgical TGF-ß decreased both in serum and exosomes as Gleason score rises. Patientś presurgical exosomes had increased CCL2, CXCL5 and TGF-ß levels than exosomes from healthy controls. These differences were not observed when cytokines were analyzed in serum, except for TGF-ß.Cytokine levels of CCL2, CXCL5 decreased in patients’ postsurgical exosomes, while TGF-ß further increased. On the contrary, S100A9 levels were lower in patientś presurgical exosomes but increased after radical prostatectomy. Conclusions: Blood exosomal content in cytokines constitute an attractive source to evaluate MDSCs immuno- modulators providing additional information related to tumor microenvironment in prostate canceres_ES
dc.description.sponsorshipThis work was supported by “Fundación José Luis Castaño-SEQCML” and “Fondo de Investigación Sanitaria” grants [PI14/00274 and PI17/00411].es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectExosomeses_ES
dc.subjectCytokineses_ES
dc.subjectCanceres_ES
dc.subjectProstatees_ES
dc.subjectMyeloid-derived suppressor cellses_ES
dc.titleCharacterization of the perioperative changes of exosomal immune-related cytokines induced by prostatectomy in early-stage prostate cancer patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open access article under the CC BY-NC-ND licensees_ES
dc.identifier.doi10.1016/j.cyto.2021.155471-
dadun.citation.number141es_ES
dadun.citation.publicationNameCytokinees_ES
dadun.citation.startingPage155471es_ES

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