Delivery of cardiovascular progenitors with biomimetic microcarriers reduces adverse ventricular remodeling in a rat model of chronic myocardial infarction
Keywords: 
Cardiac repair
Chronic myocardial infarction
Cardiovascular progenitors
Biomimetic microparticles
Extracellular vesicles
Ventricular remodeling
Issue Date: 
2021
Publisher: 
Elsevier
ISSN: 
1742-7061
Note: 
This is an open access article under the CC BY-NC-ND license
Citation: 
Garbayo, E. (Elisa); Ruiz-Villalba, A. (Adrián); Hernández, S.C. (Silvia C.); et al. "Delivery of cardiovascular progenitors with biomimetic microcarriers reduces adverse ventricular remodeling in a rat model of chronic myocardial infarction". Acta Biomaterialia. (126), 2021, 394 - 407
Abstract
Despite tremendous progress in cell-based therapies for heart repair, many challenges still exist. To en- hance the therapeutic potential of cell therapy one approach is the combination of cells with biomaterial delivery vehicles. Here, we developed a biomimetic and biodegradable micro-platform based on polymeric microparticles (MPs) capable of maximizing the therapeutic potential of cardiac progenitor cells (CPCs) and explored its efficacy in a rat model of chronic myocardial infarction. The transplantation of CPCs adhered to MPs within the infarcted myocardial microenvironment improved the long-term engraftment of trans- planted cells for up to one month. Furthermore, the enhancement of cardiac cellular retention correlated with an increase in functional recovery. In consonance, better tissue remodeling and vasculogenesis were observed in the animals treated with cells attached to MPs, which presented smaller infarct size, thicker right ventricular free wall, fewer deposition of periostin and greater density of vessels than animals treated with CPCs alone. Finally, we were able to show that part of this beneficial effect was mediated by CPC- derived extracellular vesicles (EVs). Taken together, these findings indicate that the biomimetic microcarri- ers support stem cell survival and increase cardiac function in chronic myocardial infarction through mod- ulation of cardiac remodeling, vasculogenesis and CPCs-EVs mediated therapeutic effects. The biomimetic microcarriers provide a solution for biomaterial-assisted CPC delivery to the heart.

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