Full metadata record
DC Field | Value | Language |
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dc.creator | Garbayo, E. (Elisa) | - |
dc.creator | Ruiz-Villalba, A. (Adrián) | - |
dc.creator | Hernández, S.C. (Silvia C.) | - |
dc.creator | Saludas-Echauri, L. (Laura) | - |
dc.creator | Abizanda-Sarasa, G. (Gloria) | - |
dc.creator | Pelacho, B. (Beatriz) | - |
dc.creator | Roncal, C. (Carmen) | - |
dc.creator | Sanchez, B. (Belén) | - |
dc.creator | Palacios, I. (Itziar) | - |
dc.creator | Prosper-Cardoso, F. (Felipe) | - |
dc.creator | Blanco-Prieto, M.J. (María José) | - |
dc.date.accessioned | 2022-06-28T09:44:46Z | - |
dc.date.available | 2022-06-28T09:44:46Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Garbayo, E. (Elisa); Ruiz-Villalba, A. (Adrián); Hernández, S.C. (Silvia C.); et al. "Delivery of cardiovascular progenitors with biomimetic microcarriers reduces adverse ventricular remodeling in a rat model of chronic myocardial infarction". Acta Biomaterialia. (126), 2021, 394 - 407 | es_ES |
dc.identifier.issn | 1742-7061 | - |
dc.identifier.uri | https://hdl.handle.net/10171/63703 | - |
dc.description.abstract | Despite tremendous progress in cell-based therapies for heart repair, many challenges still exist. To en- hance the therapeutic potential of cell therapy one approach is the combination of cells with biomaterial delivery vehicles. Here, we developed a biomimetic and biodegradable micro-platform based on polymeric microparticles (MPs) capable of maximizing the therapeutic potential of cardiac progenitor cells (CPCs) and explored its efficacy in a rat model of chronic myocardial infarction. The transplantation of CPCs adhered to MPs within the infarcted myocardial microenvironment improved the long-term engraftment of trans- planted cells for up to one month. Furthermore, the enhancement of cardiac cellular retention correlated with an increase in functional recovery. In consonance, better tissue remodeling and vasculogenesis were observed in the animals treated with cells attached to MPs, which presented smaller infarct size, thicker right ventricular free wall, fewer deposition of periostin and greater density of vessels than animals treated with CPCs alone. Finally, we were able to show that part of this beneficial effect was mediated by CPC- derived extracellular vesicles (EVs). Taken together, these findings indicate that the biomimetic microcarri- ers support stem cell survival and increase cardiac function in chronic myocardial infarction through mod- ulation of cardiac remodeling, vasculogenesis and CPCs-EVs mediated therapeutic effects. The biomimetic microcarriers provide a solution for biomaterial-assisted CPC delivery to the heart. | es_ES |
dc.description.sponsorship | This work was supported by the FEDER/Ministry of Science and Innovation-State Research Agency/SAF2017-83734-R and funds from the ISCIII and co-financed by FEDER (PI19/00501), Red TERCEL RETIC RD16/0011/0005 and MINECO (Program RETOS Cardiomesh RTC-2016-4911-1), ERANET II (Nanoreheart AC15/00050), and EU’s H2020 Programme for research, technological development and demonstration under grant agreement BRAV∃-874827. Elisa Garbayo is supported by a FSE/Ministry of Science and Innovation State Research Agency RYC2018-025897-I. Adrian Ruiz-Villalba is supported by the Spanish Ministry of Sciences and Innovations FSE/MINECO-AEI(IJCI-2016-30254), and the Spanish Ministerio de Ciencia, Innovación y Universidades (grant RTI2018-095410-BI00). We thank Filippo Roli and Elena Iglesias for technical support | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/874827/EU | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Cardiac repair | es_ES |
dc.subject | Chronic myocardial infarction | es_ES |
dc.subject | Cardiovascular progenitors | es_ES |
dc.subject | Biomimetic microparticles | es_ES |
dc.subject | Extracellular vesicles | es_ES |
dc.subject | Ventricular remodeling | es_ES |
dc.title | Delivery of cardiovascular progenitors with biomimetic microcarriers reduces adverse ventricular remodeling in a rat model of chronic myocardial infarction | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article under the CC BY-NC-ND license | es_ES |
dc.identifier.doi | 10.1016/j.actbio.2021.03.017 | - |
dadun.citation.endingPage | 407 | es_ES |
dadun.citation.number | 126 | es_ES |
dadun.citation.publicationName | Acta Biomaterialia | es_ES |
dadun.citation.startingPage | 394 | es_ES |
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