Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Beltrán-Hortelano, I. (Iván) | - |
dc.creator | Alcolea-Devesa, V. (Verónica) | - |
dc.creator | Font, M. (María) | - |
dc.creator | Pérez-Silanes, S. (Silvia) | - |
dc.date.accessioned | 2022-06-29T09:24:14Z | - |
dc.date.available | 2022-06-29T09:24:14Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Beltrán-Hortelano, I. (Iván); Alcolea-Devesa, V. (Verónica); Font, M. (María); et al. "Examination of multiple trypanosoma cruzi targets in a new drug discovery approach for chagas disease". Bioorganic & Medicinal Chemistry. (58), 2022, 116577 | es_ES |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | https://hdl.handle.net/10171/63734 | - |
dc.description.abstract | Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and institutions, CD is still an important human health problem worldwide. A lack of a safe and affordable treatment has led drug discovery programmes to focus, for years, on the search for molecules enabling interference with enzymes that are essential for T. cruzi survival. In this work, the authors want to offer a brief overview of the different validated targets that are involved in diverse parasite pathways: glycolysis, sterol synthesis, the de novo biosynthesis of pyrimidine nucleotides, the degradative processing of peptides and proteins, oxidative stress damage and purine salvage and nucleotide synthesis and metabolism. Their structural aspects, function, active sites, etc. were studied and considered with the aim of defining molecular bases in the search for new effective treatments for CD. This review also compiles, as much as possible, all the inhibitors reported to date against these T. cruzi targets, serving as a reference for future research in this field. | es_ES |
dc.description.sponsorship | The authors wish to express their gratitude to Fundación Caja Navarra, Obra Social la Caixa, Fundación Roviralta, Grupo Ubesol and Inversiones Garcilaso de la Vega for the financial support. Moreover, IB-H is grateful to the ISTUN Instituto de Salud Tropical of the Universidad de Navarra for the pre-doctoral fellowship. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Trypanosoma cruzi | es_ES |
dc.subject | Triosephosphate isomerase | es_ES |
dc.subject | Sterol 14α-demethylase | es_ES |
dc.subject | CYP51 | es_ES |
dc.subject | Dihydroorotate dehydrogenase | es_ES |
dc.subject | Cruzain | es_ES |
dc.subject | Trypanothione reductase | es_ES |
dc.subject | Superoxide dismutase | es_ES |
dc.subject | Pteridine reductase | es_ES |
dc.subject | Dihydrofolate reductase | es_ES |
dc.subject | Thymidylate synthase | es_ES |
dc.title | Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article under the CC BY-NC-ND license | es_ES |
dc.identifier.doi | 10.1016/j.bmc.2021.116577 | - |
dadun.citation.number | 58 | es_ES |
dadun.citation.publicationName | Bioorganic & Medicinal Chemistry | es_ES |
dadun.citation.startingPage | 116577 | es_ES |
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