Apremilast in combination with botulinum toxin-A injection for recalcitrant Hailey-Hailey disease
Keywords: 
Botulinum toxin-A
Hailey-Hailey disease
Issue Date: 
2021
Publisher: 
Wiley
ISSN: 
1365-4632
Note: 
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License
Citation: 
Antoñanzas, J. (Javier); Tomás-Velázquez, A. (Alejandra); Rodríguez-Garijo, N. (Nuria); et al. "Apremilast in combination with botulinum toxin-A injection for recalcitrant Hailey-Hailey disease". International Journal of Dermatology. (61), 2021, 600 - 602
Abstract
Hailey–Hailey disease (HHD) is a rare genodermatosis caused by a mutation in the ATP2C1 gene, which codes for a calcium channel. This ionic alteration leads to a defective keratinocyte adhesion. Hailey–Hailey disease is characterized by recurrent flare-ups of vesicles and flaccid blisters in folds that have an impact on patients’ quality of life. The recurrent and refractory nature of this condition makes its treatment a challenge. Isolated cases have been reported describing controversial results after treatment with apremilast. Here we present a case of refractory HHD who experienced an excellent response after treatment with apremilast and botulinum toxin-A (BoNT) infiltrations.

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